1. Nguva yeProthrombin (PT)

Iyo inonyanya kuratidza mamiriro eexogenous coagulation system, umo INR inowanzoshandiswa kutarisa oral anticoagulants.PT chiratidzo chakakosha chekuongororwa kwe prethrombotic state, DIC uye chirwere chechiropa.Inoshandiswa seyekuongorora bvunzo yeiyo exogenous coagulation system uye zvakare yakakosha nzira yekiriniki yemuromo anticoagulation therapy dose control.

PTA <40% inoratidza yakakura necrosis yemasero echiropa uye yakaderera synthesis ye coagulation zvinhu.Somuenzaniso, 30%

Kuwedzera kunoonekwa mu:

a.Kukuvadzwa kwakanyanya uye kwakakomba kwechiropa kunonyanya kukonzerwa nekugadzirwa kweprothrombin uye zvine chekuita nekuvhara zvinhu.

b.VitK isina kukwana, VitK inodiwa kuti igadzire zvinhu II, VII, IX, uye X. Kana VitK isina kukwana, kugadzirwa kunoderera uye nguva yeprothrombin inowedzera.Inowanikwawo mune obstructive jaundice.

C. DIC (diffuse intravascular coagulation), iyo inodya huwandu hwakawanda hwekugadzirisa zvinhu nekuda kwekuwanda kwe microvascular thrombosis.

d.Neonatal spontaneous hemorrhage, congenital prothrombin kushaya anticoagulant therapy.

Kupfupisa kunoonekwa mu:

Kana ropa riri mu hypercoagulable state (yakadai sekutanga DIC, myocardial infarction), zvirwere zvethrombotic (zvakadai secerebral thrombosis), nezvimwewo.

 

2. Thrombin nguva (TT)

Inonyanya kuratidza nguva iyo fibrinogen inoshanduka kuita fibrin.

Kuwedzera kunoonekwa mu: yakawedzera heparin kana heparinoid zvinhu, yakawedzera AT-III basa, chiyero chisina kujairika uye kunaka kwefibrinogen.DIC hyperfibrinolysis stage, yakaderera (kwete) fibrinogenemia, abnormal hemoglobinemia, blood fibrin (proto) degradation products (FDPs) yakawedzera.

Kuderedza hakuna kukosha kwekliniki.

 

3. Activated partial thromboplastin nguva (APTT)

Iyo inonyanya kuratidza mamiriro eiyo endogenous coagulation system uye inowanzoshandiswa kutarisa dosage yeheparin.Kuratidzira mazinga eiyo coagulation zvinhu VIII, IX, XI, XII muplasma, iri bvunzo yekutarisa endogenous coagulation system.APTT inowanzoshandiswa kutarisa heparin anticoagulation therapy.

Kuwedzera kunoonekwa mu:

a.Kushaya coagulation zvinhu VIII, IX, XI, XII:

b.Coagulation factor II, V, X uye fibrinogen kuderedza vashoma;

C. Kune anticoagulant zvinhu zvakadai seheparin;

d, fibrinogen degradation zvigadzirwa zvakawedzera;e, DIC.

Kupfupisa kunoonekwa mu:

Hypercoagulable state: Kana iyo procoagulant ikapinda muropa uye basa reiyo coagulation zvinhu rinowedzera, nezvimwewo:

 

4.Plasma fibrinogen (FIB)

Inonyanya kuratidza zviri mukati fibrinogen.Plasma fibrinogen ndiyo puroteni yekubatanidza ine huwandu hwepamusoro hwezvese coagulation zvinhu, uye iri acute chikamu chekupindura chinhu.

Kuwedzera kunoonekwa mu: kupisa, chirwere cheshuga, hutachiona hwehutachiona, chirwere chetachiona, kenza, subacute bacterial endocarditis, pamuviri, mabayo, cholecystitis, pericarditis, sepsis, nephrotic syndrome, uremia, acute myocardial infarction.

Kuderedza kunoonekwa mu: Congenital fibrinogen abnormality, DIC inoparadza hypocoagulation phase, primary fibrinolysis, yakanyanya hepatitis, chiropa chechiropa.

 

5.D-Dimer (D-Dimer)

Iyo inonyanya kuratidza basa re fibrinolysis uye chiratidzo chekuziva kuvapo kana kusavapo kwe thrombosis uye yechipiri fibrinolysis mumuviri.

D-dimer chinhu chakanyanya kushatisa chigadzirwa che-cross-linked fibrin, icho chinowedzera muplasma chete mushure me thrombosis, saka yakakosha molecular marker yekuongororwa kwethrombosis.

D-dimer yakawedzera zvakanyanya musecondary fibrinolysis hyperactivity, asi haina kuwedzera muprimary fibrinolysis hyperactivity, inova chiratidzo chakakosha chekusiyanisa maviri.

Kuwedzera kunoonekwa muzvirwere zvakadai seyakadzika vein thrombosis, pulmonary embolism, uye DIC yechipiri hyperfibrinolysis.