Zvidzidzo zviviri zvakakosha zveropa coagulation, activated partial thromboplastin time (APTT) uye prothrombin nguva (PT), ese ari maviri anobatsira kuona chakakonzera coagulation abnormalities.
Kuti ropa rirambe riri muchimiro chemvura,Muviri unofanirwa kuita chiito chakapfava chekuenzanisa.Ropa rinotenderera rine zvikamu zviviri zveropa, procoagulant, iyo inosimudzira ropa coagulation, uye anticoagulant, iyo inhibits coagulation, kuchengetedza kubuda kweropa.Zvisinei, kana tsinga yeropa yakakuvadzwa uye kuenzana kunovhiringidzika, procoagulant inounganidza munzvimbo yakakanganiswa uye kuvhara ropa kunotanga.Iyo nzira yekubatanidza ropa inobatanidza-ne-link, uye inogona kushandiswa neipi mbiri coagulation masisitimu akafanana, intrinsic kana extrinsic.Iyo endogenous system inogadziriswa kana ropa rasangana necollagen kana yakakuvadzwa endothelium.Iyo extrinsic system inogadziriswa kana nyama yakakuvadzwa ichiburitsa zvimwe zvinhu zve coagulation senge thromboplastin.Iyo yekupedzisira yakajairika nzira yeaviri masisitimu anotungamira kune condensation apex.Kana iyi coagulation process, kunyangwe ichiita seyakakurumidza, maviri akakosha ekuongorora bvunzo, activated partial thromboplastin nguva (APTT) uye prothrombin nguva (PT), inogona kuitwa.Kuita bvunzo idzi kunobatsira kuita ongororo yakakura yezvese coagulation abnormalities.

 

1. APTT inoratidzei?

Iyo APTT bvunzo inoongorora endo native uye yakajairika coagulation nzira.Kunyanya, inoyera kuti inotora nguva yakareba sei kuti sampuli yeropa igadzire fibrin clot nekuwedzera kwechinhu chinoshanda (calcium) uye phospholipids.Yakanyanya kunzwa uye nekukurumidza kupfuura chikamu chethromboplastin nguva.APTT inowanzoshandiswa kutarisa kurapwa nechiropa violet.

Rabhoritari yega yega ine yakajairika kukosha kweAPTT, asi kazhinji inotangira pamasekonzi gumi nematanhatu kusvika makumi mana.Nguva yakareba inogona kuratidza kusakwana kwenzvimbo yechina yegwara rekupedzisira, Xia kana chinhu, kana kushaya simba I, V kana X yenzira yakajairika.Varwere vane vhitamini K kushomeka, chirwere chechiropa, kana kuparadzira intravascular coagulopathy ichawedzera APTT.Mimwe mishonga-mishonga inorwisa mabhakitiriya, anticoagulants, narcotics, narcotics, kana aspirin inogonawo kurebesa APTT.

Kudzikira kweAPTT kunogona kuguma nekubuda ropa kwakanyanya, maronda akawandisa (kunze kwegomarara rechiropa) uye kumwe kurapwa kwezvinodhaka kunosanganisira antihistamines, antacids, digitalis gadziriro, nezvimwe.

2. Chii chinoratidza PT?

Iyo PT assay inoongorora extrinsic uye yakajairika clotting nzira.Yekutarisa kurapwa ne anticoagulants.Muedzo uyu unoyera nguva inotora kuti plasma ivhare mushure mekuwedzerwa kwetishu factor uye calcium kusampuli yeropa.Yakajairika yakajairika renji yePT ndeye 11 kusvika 16 masekonzi.Kuwedzerwa kwePT kunogona kuratidza kushomeka kwethrombin profibrinogen kana factor V, W kana X.

Varwere vanorutsa, manyoka, kudya miriwo yemashizha egirinhi, doro kana kurapwa kwenguva refu nemishonga inorwisa mabhakitiriya, antihypertensives, oral anticoagulants, narcotics, uye mahombe easpirin anogonawo kurebesa PT.Low-giredhi PT inogonawo kukonzerwa ne antihistamine barbiturates, antacids, kana vhitamini K.

Kana PT yemurwere ichidarika masekonzi makumi mana, intramuscular vitamin K kana fresh-yakaomeswa nechando plasma inozodiwa.Nguva nenguva ongorora kubuda ropa kwemurwere, ongorora mamiriro ake etsinga, uye ongorora ropa remashiripiti muweti netsvina.

 

3. Tsanangura migumisiro yacho

Murwere ane abnormal coagulation kazhinji anoda bvunzo mbiri, APTT nePT, uye anozoda kuti ududzire mhinduro idzi, upfuure bvunzo dzenguva idzi, uye pakupedzisira kuronga kurapwa kwake.