Vatsvagiri vepaMonash University vakagadzira antibody nyowani inogona kuvharira puroteni muropa kudzivirira thrombosis pasina mhedzisiro.Iyi antibody inogona kudzivirira pathological thrombosis, iyo inogona kukonzera kurova kwemoyo uye sitiroko pasina kukanganisa yakajairika ropa clotting basa.

Kurova kwemoyo uye sitiroko zvinoramba zviri izvo zvinotungamira zvekufa uye kurwara pasi rose.Ikozvino antithrombotic (anticoagulant) kurapa kunogona uye kukonzeresa matambudziko akakomba ekubuda ropa nekuti anokanganisawo kugwamba kweropa.Zvikamu zvina kubva muzvishanu zvevarwere vanowana antiplatelet therapy vachine zviitiko zvemoyo zvinowanzoitika.

Naizvozvo, iyo iripo antiplatelet mishonga haigone kushandiswa muhuwandu hwakakura.Naizvozvo, kushanda kwekiriniki kuchiri kuodza mwoyo, uye marapiro emangwana anofanirwa kugadzirwa patsva.

Nzira yekutsvagisa ndeyekutanga kuona musiyano webiological pakati peyakajairwa coagulation uye pathological coagulation, uye kuona kuti von Willebrand factor (VWF) inoshandura zvimiro zvayo kana thrombus ine njodzi yaumbwa.Chidzidzo ichi chakagadzira masoja ekudzivirira chirwere anongoona nekuvharisa iyi pathological form yeVWF, nekuti inongoshanda chete kana clot yeropa yava pathological.

Chidzidzo ichi chakaongorora hunhu hweapo anti-VWF masoja ekudzivirira chirwere uye akaona akanakisa hunhu hwemunhu wega wega anosunga uye kuvhara VWF pasi pepathological coagulation mamiriro.Kana pakashaikwa chero maitiro asina kunaka, masoja ekudzivirira chirwere aya anotanga asanganiswa kuita chimiro chitsva cheropa kudzivirira matambudziko angangoitika aya.

Varapi parizvino vakatarisana nekudzikama pakati pekuita kwezvinodhaka uye kubuda ropa.Injiniya inorwisa masoja akanyatsogadzirwa uye haizokanganise neyakajairwa ropa coagulation, saka zvinotarisirwa kuti inogona kushandisa yakakwira uye inoshanda zvakanyanya kupfuura marapirwo aripo.

Ichi chidzidzo che in vitro chakaitwa nemasampuli eropa revanhu.Danho rinotevera nderekuyedza kushanda kwemasoja ekudzivirira chirwere mumhando yemhuka diki kuti unzwisise kuti inoshanda sei mukurarama kwakaoma kwakafanana neyedu.

Reference: Thomas Hoefer et al.Targeting shear gradient activated von Willebrand factor neinoveli single-chain antibody A1 inoderedza occlusive thrombus kuumbwa mu vitro, Haematologica (2020).