01.Kuongororwa kwemvura yakadzika thrombosis uye pulmonary embolism

Deep vein thrombosis (D-VT) inowanzoita pulmonary embolism (PE), pamwe chete inozivikanwa sevenous thromboembolism (VTE).Plasma D-dimer mazinga akanyanya kukwidziridzwa muVTE varwere.

Zvidzidzo zvakabatana zvakaratidza kuti plasma D-dimer concentration muvarwere vane PE uye D-VT yakakura kupfuura 1 000 μg/L.

Nekudaro, nekuda kwezvirwere zvakawanda kana zvimwe pathological zvikonzero (kuvhiyiwa, mapundu, chirwere chemwoyo, nezvimwewo) zvine zvimwe zvinokanganisa hemostasis, zvichikonzera kuwedzera D-dimer.Nokudaro, kunyange zvazvo D-dimer ine kunzwisiswa kwepamusoro, iyo chaiyo inongova 50% kusvika 70%, uye D-dimer chete haigoni kuongorora VTE.Nokudaro, kuwedzera kukuru kweD-dimer hakugoni kushandiswa sechiratidzo chaicho cheVTE.Izvo zvakakosha zvekuongororwa kweD-dimer ndezvekuti mhedzisiro yakaipa inodzivirira kuongororwa kweVTE.

 

02 Yakaparadzirwa intravascular coagulation

Disseminated intravascular coagulation (DIC) chirwere chekuwedzera microthrombosis mumidziyo miduku mumuviri wose uye yechipiri hyperfibrinolysis pasi pechiito chezvimwe zvinokonzera pathogenic, iyo inogona kuperekedzwa nechipiri fibrinolysis kana inhibited fibrinolysis.

Iyo yakakwira plasma yemukati yeD-dimer ine yakakwira kiriniki yereferensi kukosha kwekutanga kuongororwa kweDIC.Zvisinei, zvinofanira kuonekwa kuti kuwedzera kweD-dimer hakusi muedzo chaiwo weDIC, asi zvirwere zvakawanda zvinoperekedzwa ne microthrombosis zvinogona kutungamirira kukuwedzera kweD-dimer.Kana fibrinolysis iri yechipiri kune extravascular coagulation, D-dimer inowedzerawo.

Zvidzidzo zvakaratidza kuti D-dimer inotanga kusimuka mazuva DIC isati yasvika uye yakanyanya kukwirira kupfuura yakajairika.

 

03 Neonatal asphyxia

Kune madhigirii akasiyana e hypoxia uye acidosis mune neonatal asphyxia, uye hypoxia uye acidosis inogona kukonzera yakakura vascular endothelial kukuvadzwa, zvichikonzera kuburitswa kwehuwandu hwe coagulation zvinhu, nekudaro kuwedzera kugadzirwa kwefibrinogen.

Zvidzidzo zvakakosha zvakaratidza kuti D-dimer kukosha kwetambo yeropa muboka reasphyxia yakanyanya kukwirira kupfuura yeboka rinowanzodzora, uye kana ichienzaniswa neiyo D-dimer kukosha muropa reperipheral, zvakare yakakwira zvakanyanya.

 

04 Systemic lupus erythematosus (SLE)

Iko-coagulation-fibrinolysis system haina kukwana muvarwere veSLE, uye kusakanganiswa kwe-coagulation-fibrinolysis system kunonyanya kutaurwa muchikamu chekushanda kwechirwere, uye tsika ye thrombosis inonyanya kuoneka;apo chirwere chacho chasunungurwa, iyo coagulation-fibrinolysis system inowanzova yakajairika.

Naizvozvo, iyo D-dimer mazinga evarwere vane systemic lupus erythematosus mumatanho anoshanda uye asingashande achawedzerwa zvakanyanya, uye plasma D-dimer mazinga evarwere vari muchikamu chekushanda akakwira zvakanyanya kupfuura avo vari muchikamu chisingaiti.

05 Chiropa cirrhosis uye gomarara rechiropa

D-dimer chimwe chezviratidzo zvinoratidza kuoma kwechirwere chechiropa.Kunyanya kuoma kwechirwere chechiropa, kunowedzera plasma D-dimer content.

Zvidzidzo zvakakosha zvakaratidza kuti D-dimer kukosha kweMwana-Pugh A, B, uye C mamakisi muvarwere vane chiropa cirrhosis aive (2.218 ± 0.54) μg/mL, (6.03 ± 0.76) μg/mL, uye (10.536 ± 0.664) μg/mL, zvichiteerana..

Mukuwedzera, D-dimer yakasimudzwa zvakanyanya kune varwere vane kenza yechiropa nekukurumidza kufambira mberi uye kufungidzira kwakashata.

06 Gomarara remudumbu

Mushure mekugadziriswa kwevarwere vekenza, thromboembolism inoitika munenge hafu yevarwere, uye D-dimer inowedzera zvakanyanya mu90% yevarwere.

Pamusoro pezvo, kune kirasi yemhando yepamusoro-shuga mumasero ebundu ane chimiro uye tishu chinhu chakafanana.Kutora chikamu mumabasa emasabolism emunhu anogona kusimudzira basa remuviri coagulation system uye kuwedzera njodzi yethrombosis, uye nhanho yeD-dimer inowedzera zvakanyanya.Uye iyo nhanho yeD-dimer mugomarara remudumbu varwere vane nhanho III-IV yaive yakanyanya kukwirira kupfuura iyo mugastric cancer varwere vane nhanho I-II.

 

07 Mycoplasma mabayo (MMP)

Yakanyanya MPP inowanzo perekedzwa neakakwira D-dimer mazinga, uye D-dimer mazinga akakwira zvakanyanya muvarwere vane MPP yakaoma kupfuura mune zvinyoro.

Kana MPP ichirwara zvakanyanya, hypoxia, ischemia uye acidosis ichaitika munharaunda, pamwe chete nekupinda kwakananga kwehutachiona, izvo zvinokuvadza vascular endothelial masero, kubudisa collagen, activate coagulation system, kuumba hypercoagulable state, uye kuumba microthrombi.Iyo yemukati fibrinolytic, kinin uye complement masisitimu zvakare inogadziriswa zvakatevedzana, zvichikonzera kuwedzera kweD-dimer mazinga.

 

08 Chirwere cheshuga, chirwere cheshuga nephropathy

D-dimer mazinga akanyanya kukwidziridzwa kune varwere vane chirwere cheshuga uye chirwere cheshuga nephropathy.

Mukuwedzera, iyo D-dimer uye fibrinogen indexes yevarwere vane chirwere cheshuga nephropathy yakanga yakakwirira zvikuru kupfuura yevaya vane chirwere cheshuga chechipiri.Naizvozvo, mukuita kwekiriniki, D-dimer inogona kushandiswa seyedzo index yekuongorora kuomarara kwechirwere cheshuga uye chirwere cheitsvo muvarwere.

09 Allergic Purpura (AP)

Muchikamu chakaoma cheAP, kune madhigirii akasiyana eropa hypercoagulability uye kuwedzeredzwa kweplatelet basa, zvichitungamira kune vasospasm, platelet aggregation uye thrombosis.

Yakakwira D-dimer muvana vane AP inowanzoitika mushure memavhiki maviri ekutanga uye inosiyana pakati pematanho ekiriniki, zvichiratidza huwandu uye chiyero che systemic vascular kuzvimba.

Mukuwedzera, ihwowo chiratidzo chekufungidzira, nekuramba kwakakwirira kweD-dimer, chirwere chacho chinowanzorebeswa uye chinowanzoita kukuvara kwetsvo.

 

10 Kubata pamuviri

Zvidzidzo zvine hukama zvakaratidza kuti vangangosvika gumi muzana yevakadzi vane pamuviri vakanyanya kukwidza mazinga eD-dimer, zvichiratidza njodzi yekugwamba kweropa.

Preeclampsia inowanzoitika pakubata pamuviri.Iko huru pathological shanduko ye preeclampsia uye eclampsia ndeye coagulation activation uye fibrinolysis kuwedzera, zvichikonzera kuwedzera microvascular thrombosis uye D-dimer.

D-dimer yakadzikira nekukurumidza mushure mekusununguka muvakadziwo zvavo, asi yakawedzera muvakadzi vane preeclampsia, uye haina kudzokera kune yakajairika kusvika 4 kusvika mavhiki matanhatu.

11 Acute Coronary Syndrome uye Dissecting Aneurysm

Varwere vane acute coronary syndromes vane zvakajairwa kana kuti zvinyoro zvakasimudzwa D-dimer mazinga, nepo aortic dissecting aneurysms yakakwira zvakanyanya.

Izvi zvakabatana nekusiyana kwakakosha mumutoro we thrombus mumidziyo ye arterial yezviviri.Iyo coronary lumen yakatetepa uye thrombus mucoronary artery ishoma.Mushure mokunge aortic intima kuputika, ropa guru reropa rinopinda mumadziro emudziyo kuti riite dissecting aneurysm.Nhamba huru ye thrombi inoumbwa pasi pechiito che coagulation mechanism.

12 Acute cerebral infarction

Mune acute cerebral infarction, kungoerekana thrombolysis uye yechipiri fibrinolytic basa inowedzerwa, inoratidzwa sekuwedzera kweplasma D-dimer mazinga.Iyo D-dimer level yakawedzera zvakanyanya muchikamu chekutanga cheacute cerebral infarction.

Plasma D-dimer mazinga muvarwere vane acute ischemic sitiroko yakawedzera zvishoma muvhiki yekutanga mushure mekutanga, yakawedzera zvakanyanya mu2 kusvika kumavhiki e4, uye yakanga isina kusiyana nemazinga akajairika panguva yekupora (> 3 mwedzi).