Ropa coagulation diagnostic inogara ichinyorwa navanachiremba.Varwere vane mamwe mamiriro ekurapa kana avo vari kutora anticoagulant zvinodhaka vanofanirwa kuongorora ropa coagulation.Asi nhamba dzakawanda kudaro dzinorevei?Ndezvipi zviratidzo zvinofanira kuongororwa kliniki kune zvirwere zvakasiyana?
Coagulation function test indexes dzinosanganisira prothrombin nguva (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB), Clotting time (CT) uye International normalized ratio (INR), nezvimwewo, zvinhu zvakawanda zvinogona kuva yakasarudzwa kugadzira pasuru, iyo inonzi coagulation X chinhu.Nekuda kwenzira dzakasiyana dzekuona dzinoshandiswa nezvipatara zvakasiyana, mareferenzi akasiyana zvakare.
PT-prothrombin nguva
PT inoreva kuwedzera tissue factor (TF kana tissue thromboplastin) uye Ca2 + kuplasma kuti itange extrinsic coagulation system uye inocherechedza nguva yekubatanidza yeplasma.PT ndeimwe yezvinonyanya kushandiswa kuongorora bvunzo mumakiriniki maitiro kuti aongorore basa rekunze coagulation nzira.Yakajairika referensi kukosha ndeye 10 kusvika 14 masekonzi.
APTT - activated partial thromboplastin nguva
APTT ndeyekuwedzera XII factor activator, Ca2 +, phospholipid ku plasma kuti itange plasma endogenous coagulation nzira, uye cherechedza nguva yeplasma coagulation.APTT zvakare imwe yeanonyanya kushandiswa kuongorora bvunzo mukiriniki maitiro kuti aongorore basa reiyo intrinsic coagulation nzira.Yakajairika referensi kukosha ndeye 32 kusvika 43 masekonzi.
INR - International Normalized Ratio
INR isimba reISI rechiyero chePT yemurwere akaedzwa kusvika kuPT yekutonga kwakajairika (ISI indekisi yepasi rose senitivity, uye reagent inogadziriswa nemugadziri kana ichibva mufekitori).Iyo plasma imwechete yakaedzwa nemareagents akasiyana eISI mumarabhoritari akasiyana, uye mhedzisiro yekukosha kwePT yaive yakasiyana zvakanyanya, asi yakayerwa INR tsika dzaive dzakafanana, izvo zvakaita kuti mhedzisiro ienzane.Yakajairika referensi kukosha ndeye 0.9 kusvika 1.1.
TT-thrombin nguva
TT ndeyekuwedzerwa kweyero thrombin kuplasma kuti ione chikamu chechitatu chekugadzirisa, kuratidza chiyero che fibrinogen mu plasma uye chiyero cheheparin-sezvinhu mu plasma.Yakajairika referensi kukosha ndeye 16 kusvika 18 masekonzi.
FIB-fibrinogen
FIB ndeyekuwedzera imwe huwandu hwethrombin kune yakaedzwa plasma kushandura fibrinogen muplasma kuita fibrin, uye kuverenga zvirimo zvefibrinogen kuburikidza neiyo turbidimetric musimboti.Yakajairika referensi kukosha ndeye 2 kusvika 4 g/L.
FDP-plasma fibrin degradation chigadzirwa
FDP ishoko rakajairwa rekusvibisa zvigadzirwa zvinogadzirwa mushure mekunge fibrin kana fibrinogen yaora pasi pechiito cheplasmin chinogadzirwa panguva ye hyperfibrinolysis.Yakajairika referensi kukosha ndeye 1 kusvika 5 mg/L.
CT-coagulation nguva
CT inoreva nguva iyo ropa rinobva mutsinga uye rinobatana mu vitro.Iyo inonyanya kuona kana zvakasiyana-siyana coagulation zvinhu mu intrinsic coagulation nzira iri kushomeka, kana basa ravo rakajairwa, kana kuti kune kuwedzera kweanticoagulant zvinhu.