Chiropa inzvimbo yekugadzira zvakasiyana-siyana coagulation zvinhu, uye inogona kusanganisa uye kusaita fibrin lysates uye antifibrinolytic zvinhu, uye kuita basa rekutonga mukuchengetedza chiyero chesimba cheiyo coagulation uye anticoagulation system.Kuonekwa kweropa coagulation indexes kune varwere vane hepatitis B kwakaratidza kuti kwakanga kusina kusiyana kwakasiyana muPTAPTT kune varwere vane chirwere chisingaperi chehepatitis B kana chichienzaniswa neboka rekutonga (P> 0.05), asi pakanga pane musiyano mukuru muFIB (P <0.05). )Pakanga pane misiyano yakakura muPT, APTT, uye FIB pakati peboka rakanyanya hepatitis B neboka rinowanzodzora (P <005P <0.01), izvo zvakaratidza kuti kuoma kwehepatitis B kwakabatana zvakanaka nekuderedza kweropa coagulation factor levels.

Ongororo yezvikonzero zvemhedzisiro iri pamusoro:

1. Kunze kwechikonzero IV (Ca *) uye cytoplasm, mamwe maitiro e plasma coagulation anogadzirwa muchiropa;anticoagulation factor (coagulation inhibitors) yakadai seATIPC, 2-MaI-AT, nezvimwewo inogadzirwawo nechiropa.cellular synthesis.Kana masero echiropa akakuvadzwa kana necrotic kune madhigirii akasiyana, kugona kwechiropa kugadzira coagulation zvinhu uye anti-coagulation zvinhu zvinodzikiswa, uye mazinga eplasma ezvinhu izvi anoderedzwawo, zvichikonzera zvipingamupinyi kune coagulation mechanism.PT ndiyo yekuongorora yekuongorora ye extrinsic coagulation system, iyo inogona kuratidza chiyero, basa uye basa re coagulation factor IV VX mu plasma.Kuderedzwa kwezvinhu zviri pamusoro apa kana kuchinja kwemabasa avo nemabasa kwakava chimwe chezvikonzero zvekugara kwenguva refu kwePT kune varwere vane post-hepatitis B cirrhosis uye yakaoma hepatitis B. Nokudaro, PT inowanzoshandiswa kuchipatara kuratidza kuumbwa kwe coagulation. zvinhu muchiropa.

2. Kune rumwe rutivi, nekukuvadzwa kwemasero echiropa uye kukanganisa kwechiropa muvarwere vehepatitis B, chiyero che plasmin mu plasma chinowedzera panguva ino.Plasmin haingogone chete hydrolyze yakawanda yefibrin, fibrinogen uye akawanda coagulation zvinhu senge factor kudzidziswa, XXX, VVII,Ⅱ, zvichingodaro, asi zvakare inodya huwandu hukuru hweanti-coagulation zvinhu zvakaita seATⅢPC uye zvichingodaro.Nokudaro, nekuwedzera kwechirwere, APTT yakawedzera uye FIB yakaderera zvakanyanya muvarwere vehepatitis B.

Mukupedzisa, kuongororwa kweiyo coagulation indexes yakadai sePTAPTTFIB ine zvakakosha zvikuru zvekliniki zvakakosha pakutonga mamiriro evarwere vane chirwere chisingaperi chehepatitis B, uye inonzwisisika uye yakavimbika yekuongorora index.