Zvinokwanisika kuziva kana murwere ane abnormal coagulation basa asati avhiyiwa, zvinobudirira kudzivirira mamiriro asingatarisirwi akadai seasina kumira kubuda ropa panguva uye mushure mekuvhiyiwa, kuitira kuti uwane yakanakisa yekuvhiya maitiro.
Basa remuviri rehemostatic rinoitwa nekubatana kwekuita kweplatelet, coagulation system, fibrinolytic system uye vascular endothelial system.Munguva yakapfuura, takashandisa nguva yekubuda ropa seyedzo yekuongorora yehemostatic function defects, asi nekuda kwekuderera kwayo, kusanzwa zvakanaka, uye kusakwanisa kuratidza zviri mukati uye chiitiko che coagulation zvinhu, yakatsiviwa ne coagulation basa bvunzo.Coagulation basa bvunzo dzinonyanya kusanganisira plasma prothrombin nguva (PT) uye PT chiitiko chakaverengerwa kubva kuPT, international normalized ratio (INR), fibrinogen (FIB), activated partial thromboplastin time (APTT) uye plasma thrombin time (TT).
PT inonyanya kuratidza basa re extrinsic coagulation system.Yakareba PT inonyanya kuonekwa mu congenital coagulation factor II, V, VII, uye X kuderedza, fibrinogen kushomeka, kuwana coagulation factor deficiency (DIC, primary hyperfibrinolysis, obstructive jaundice, vitamin K kushomeka, uye anticoagulant zvinhu mukutenderera kweropa. inonyanya kuonekwa mu congenital coagulation factor V kuwedzera, kutanga kweDIC, zvirwere zvethrombotic, mishonga yekudzivirira pamuviri, nezvimwewo; kutarisa PT kunogona kushandiswa sekutarisa kwekliniki yemuromo anticoagulant zvinodhaka.
APTT ndiyo yakavimbika yekuongorora bvunzo ye endogenous coagulation factor kushomeka.APTT yenguva refu inonyanya kuonekwa muhemophilia, DIC, chirwere chechiropa, uye kuwedzerwa kukuru kweropa rebhangi.Yakapfupikiswa APTT inonyanya kuonekwa muDIC, prothrombotic state, uye thrombotic zvirwere.APTT inogona kushandiswa sechiratidzo chekutarisa chekurapa heparin.
TT kuwedzera kunoonekwa mu hypofibrinogenemia uye dysfibrinogenemia, yakawedzera FDP muropa (DIC), uye kuvapo kweheparin uye heparinoid zvinhu muropa (semuenzaniso, panguva yeheparin therapy, SLE, chirwere chechiropa, nezvimwewo).
Pakambove nemurwere wekukurumidzira akagamuchira preoperative laboratory bvunzo, uye mhedzisiro yecoagulation bvunzo yakarebesa PT uye APTT, uye DIC yaifungidzirwa mune murwere.Pasi pekurudziro yerabhoritari, murwere akaita ongororo dzakatevedzana dzeDIC uye mhedzisiro yacho yaive yakanaka.Hapana zviratidzo zviri pachena zveDIC.Kana murwere asina coagulation test, uye kuvhiyiwa zvakananga, migumisiro ichava yakaipa.Mazhinji matambudziko akadai anogona kuwanikwa kubva kune coagulation basa bvunzo, iyo yakatenga yakawanda nguva yekuonekwa kwekiriniki uye kurapwa kwezvirwere.Coagulation series test test yakakosha murabhoritari yevarwere 'coagulation function, iyo inogona kuona abnormal coagulation basa muvarwere vasati vavhiyiwa, uye inofanirwa kutariswa zvakakwana.
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