Muviri wakajairika une yakazara coagulation uye anticoagulation system.Iyo coagulation system uye iyo anticoagulation system inochengetedza chiyero chine simba kuti ive nechokwadi chehemostasis yemuviri uye kuyerera kweropa.Kamwe iyo coagulation uye anticoagulation basa chiyero ichikanganiswa, zvinotungamira mukubuda ropa uye thrombosis maitiro.

1. Kukoira kwemuviri kushanda

Iyo coagulation system inonyanya kuumbwa ne coagulation zvinhu.Izvo zvinhu zvinobatanidzwa zvakananga mukugadzika zvinodaidzwa kuti coagulation factor.Pane 13 inozivikanwa coagulation zvinhu.

Kune endogenous activation nzira uye exogenous activation nzira dze activation ye coagulation zvinhu.

Parizvino zvinotendwa kuti kushandiswa kweiyo exogenous coagulation system yakatangwa netishu chinhu chinoita basa guru mukutanga kwekubatana.Kubatana kwepedyo pakati pemukati uye kunze coagulation systems inoita basa rinokosha mukutanga nekuchengetedza coagulation process.

2. Basa rekudzivirira kwemuviri

Anticoagulation system inosanganisira cellular anticoagulation system uye body fluid anticoagulation system.

①Sero anticoagulation system

Inoreva phagocytosis ye coagulation factor, tissue factor, prothrombin complex uye soluble fibrin monomer ne mononuclear-phagocyte system.

②Body fluid anticoagulation system

Kusanganisira: serine protease inhibitors, mapuroteni C-based protease inhibitors uye tissue factor pathway inhibitors (TFPI).

3. Fibrinolytic system nemabasa ayo

Kunyanya zvinosanganisira plasminogen, plasmin, plasminogen activator uye fibrinolysis inhibitor.

Basa re fibrinolytic system: nyungudutsa fibrin clots uye chengetedza kufamba kwakanaka kweropa;kutora chikamu mukugadziriswa kwetishu uye kuvandudzwa kwevascular.

4. Basa revascular endothelial masero mukuita coagulation, anticoagulation uye fibrinolysis.

① Gadzira zvakasiyana-siyana biologically inoshanda zvinhu;

②Regulate ropa coagulation uye anticoagulation basa;

③Gadzirisa basa re fibrinolysis system;

④ Regulate vascular tension;

⑤Kutora chikamu mukuyananisa kwekuzvimba;

⑥Chengetedza basa re microcirculation, nezvimwe.

Coagulation uye anticoagulant kusagadzikana

1. Abnormalities mune coagulation zvinhu.

2. Kusagadzikana kwezvinhu zveanticoagulant muplasma.

3. Kusagadzikana kwefibrinolytic factor muplasma.

4. Kusagadzikana kwemasero eropa.

5. Mitsipa yeropa isina kujairika.