Prothrombin nguva (PT) chiratidzo chakakosha kwazvo kuratidza chiropa synthesis basa, kuchengetedza basa, kuomarara kwechirwere uye kufungidzira.Parizvino, kuongororwa kwekliniki yehutano hwekugadzirisa zvinhu kwave kuchiitika, uye ichapa ruzivo rwekare uye rwakarurama kupfuura PT mukutonga mamiriro echirwere chechiropa.

Clinical kushandiswa kwePT muchirwere chechiropa:

Murabhoritari inoshuma PT nenzira ina: prothrombintime chiitikopercentagePTA (prothrombin time ratio PTR) uye international normalized ratio INR.Mafomu mana ane maitiro akasiyana ekushandiswa kwekliniki.

Kukosha kwekushandiswa kwePT muhosha yechiropa: PT inonyanya kugadziriswa nehuwandu hwekugadzirisa chinhu IIvX yakagadzirwa nechiropa, uye basa rayo muchirwere chechiropa chinonyanya kukosha.Chiyero chisina kujairika chePT muacute hepatitis yaive 10% -15%, chisingaperi hepatitis yaive 15% -51%, cirrhosis yaive 71%, uye yakanyanya hepatitis yaive 90%.Muchirongwa chekuongororwa kwehutachiwana hwehepatitis muna 2000, PTA chimwe chezviratidzo zvechipatara chevarwere vane viral hepatitis.Chronic viral hepatitis varwere vane nyoro PTA> 70%, pakati nepakati 70% -60%, yakaoma 60% -40%;cirrhosis neyakabhadharwa nhanho PTA> 60% decompensated danho PTA <60%;yakanyanya hepatitis PTA <40%" MuChild-Pugh classification, 1 point yePT kuwedzera kwe1 ~ 4s, 2 points ye 4 ~ 6s, 3 points ye> 6s, yakasanganiswa nezvimwe zviratidzo zvina (albumin, bilirubin, ascites, encephalopathy ), chiropa chinoshanda chevarwere vane chirwere chechiropa Reserves chakakamurwa kuva ABC mamakisi; MELD mamakisi (Modelfor end-stageliver disease), iyo inotarisa kuoma kwechirwere kune varwere vane chirwere chekupedzisira chechiropa uye kutevedzana kwechiropa chechiropa, the fomula inoti .8xloge[bilirubin(mg/dl)+11.2xloge(INR)+ 9.6xloge[creatinine (mg/dl]+6.4x (chikonzero: biliary kana doro 0; imwe 1), INR chimwe chezviratidzi zvitatu.

DIC diagnostic maitiro echirwere chechiropa anosanganisira: PT kuwedzera kweanopfuura 5s kana activated partial thromboplastin nguva (APTT) kweanopfuura 10s, factor VIII basa <50% (inodiwa);PT uye platelet count inowanzoshandiswa kuongorora chiropa biopsy uye kuvhiyiwa Kubuda ropa kwevarwere, zvakadai semaplatelet <50x10 ° / L, uye PT kuwedzeredza kudarika kwakajairika kune 4s kunopesana nechiropa chebiopsy uye kuvhiyiwa kunosanganisira kuiswa kwechiropa.Zvinogona kuonekwa kuti PT inobata basa rinokosha pakuongorora uye kurapwa kwevarwere vane chirwere chechiropa.