Fa'aaogāga fa'asoifua maloloina ole fa'ato'a toto ile ma'i cardiovascular ma cerebrovascular(1)


Tusitala: Sui   

1. Fa'aaogāga fa'afoma'i o galuega fa'ato'a toto i fa'ama'i fatu ma fatu

I le lalolagi atoa, o le numera o tagata o loʻo mafatia i faʻamaʻi cardiovascular ma cerebrovascular e toʻatele, ma o loʻo faʻaalia ai le faʻatupulaia o le faʻasologa i lea tausaga ma lea tausaga.I faʻataʻitaʻiga faʻataʻitaʻi, o tagata gasegase masani e puupuu le taimi e amata ai ma o loʻo faʻatasi ma le cerebral hemorrhage, lea e afaina ai le faʻamaʻi ma lamatia ai le saogalemu o le ola o tagata gasegase.
E tele faʻamaʻi o faʻamaʻi cardiovascular ma cerebrovascular, ma o latou aʻafiaga e matua faigata foi.Faatasi ai ma le faʻaauau pea o le faʻalauteleina o suʻesuʻega faʻapitoa i luga o le coagulation, ua maua ai i faʻamaʻi cardiovascular ma cerebrovascular, e mafai foi ona faʻaaogaina mea faʻapipiʻi e avea ma aʻafiaga mo lenei maʻi.O su'esu'ega fa'afoma'i ua fa'aalia ai o auala fa'ato'aga fa'apitoa ma fa'alavelave fa'apenei o ia gasegase o le a iai se a'afiaga i su'esu'ega, su'esu'ega ma fa'amasani o ia fa'ama'i.O le mea lea, o se suʻesuʻega atoatoa o le faʻamaʻi pipisi o tagata mamaʻi e taua tele mo tagata mamaʻi e maua i faʻamaʻi cardiovascular ma cerebrovascular.taua.

2. Aisea e tatau ai i tagata mamaʻi e maua i le fatu ma faʻamaʻi o le cerebrovascular ona gauai atu i faʻailoga o le coagulation

O fa'ama'i fatu fatu ma fa'ama'i fatu o fa'ama'i ia e matua'i lamatia ai le soifua maloloina ma le ola o tagata, e maualuga le oti ma le maualuga o le fa'aletonu.
E ala i le suʻesuʻeina o le gaioiga o le coagulation i tagata mamaʻi e maua i faʻamaʻi cardiovascular ma cerebrovascular, e mafai ona iloilo pe o le tagata maʻi e maua i le toto ma le lamatiaga o le venous thrombosis;i le faagasologa o togafitiga faʻamaʻi mulimuli ane, e mafai foi ona suʻesuʻeina le aʻafiaga o le anticoagulation ma e mafai ona taʻitaʻia vailaʻau falemaʻi e aloese ai mai le tafe toto.

1).Tagata ma'i stroke

O le ta'i o le cardioembolic ose fa'ama'i fa'ama'i e mafua mai i le fa'amaligiina o le ma'i fatu ma fa'apupulaina alatoto o le cerebral, e tusa ma le 14% i le 30% o fa'ama'i uma.Faatasi ai ma i latou, o le atrial fibrillation-related stroke accounts mo le sili atu i le 79% o taʻaloga cardioembolic uma, ma le cardioembolic strokes e sili atu ona ogaoga, ma e tatau ona vave iloa ma faʻamalosi malosi.Ina ia iloilo le tulaga lamatia thrombosis ma anticoagulation togafitiga o gasegase, ma anticoagulation togafitiga falemai manaomia e faaaoga faailoga coagulation e iloilo ai le aafiaga anticoagulation ma anticoagulation saʻo vailaau e puipuia ai le toto.

O le lamatiaga sili i tagata mamaʻi e maua i le atrial fibrillation o le arterial thrombosis, aemaise le cerebral embolism.Fautuaga anticoagulation mo le cerebral infarction lona lua ile atrial fibrillation:
1. E le fautuaina le fa'aaogaina vave o vaila'au fa'ama'i mo tagata mama'i e maua i le fa'alavelave fa'afuase'i o le cerebral infarction.
2. I tagata gasegase e togafitia i le thrombolysis, e masani lava e le fautuaina e faʻaoga anticoagulants i totonu ole 24 itula.
3. Afai e leai ni faʻalavelave e pei o le tafe toto, maʻi ogaoga o le ate ma fatugaʻo, toto maualuga> 180 / 100mmHg, ma isi, o tulaga nei e mafai ona manatu e faʻaaoga filifilia o anticoagulants:
(1) O tagata mama'i e maua i le fatu (e pei o le valve fa'akomepiuta, fibrillation atrial, myocardial infarction with mural thrombus, left atrial thrombosis, etc.) e faigofie ona toe oso.
(2) O maʻi e maua i le faʻamaʻi faʻamaʻi faʻatasi ma le protein C deficiency, protein S deficiency, malosi protein C teteʻe ma isi gasegase thromboprone;tagata mama'i e fa'ama'i fa'ama'i fa'ama'i fa'ama'i fa'ama'i;tagata mama'i e maua i totonu o le toto ma le toto.
(3) E mafai ona fa'aogaina e tagata mama'i fa'amoe e maua i le cerebral infarction e maualalo le fua o le heparin po'o le fua tutusa o le LMWH e puipuia ai le thrombosis vein loloto ma le pulmonary embolism.

2).Le taua o le mata'ituina o le fa'asologa o le coagulation pe a fa'aaoga vaila'au fa'ama'i

• PT: E lelei le fa'atinoga o le INR a le falesu'esu'e ma e mafai ona fa'aoga e ta'ita'ia ai le fetuunaiga o fua ole warfarin;iloilo le tulaga lamatia o le toto o rivaroxaban ma edoxaban.
• APTT: E mafai ona fa'aoga e iloilo ai le aoga ma le saogalemu o (tulaga feololo) e le'i fa'avasegaina le heparin ma ia iloilo lelei le tulaga lamatia o le toto o le dabigatran.
• TT: Ma'ale'ale ile dabigatran, fa'aoga e fa'amaonia ai le dabigatran o totoe ile toto.
• D-Dimer/FDP: E mafai ona fa'aoga e iloilo ai le a'afiaga o vaila'au fa'aanticoagulant e pei ole warfarin ma le heparin;ma ia iloilo le aʻafiaga o vailaʻau thrombolytic e pei ole urokinase, streptokinase, ma alteplase.
• AT-III: E mafai ona faʻaaogaina e taʻitaʻia ai aʻafiaga o vailaʻau o le heparin, le mamafa o le molecular heparin, ma le fondaparinux, ma faʻaalia pe tatau ona sui anticoagulants i le falemaʻi.

3).Anticoagulation a'o le'i faia ma ina ua uma le cardioversion ole atrial fibrillation

E iai le lamatiaga o le thromboembolism i le taimi o le cardioversion o le fibrillation atrial, ma o togafitiga talafeagai e mafai ona faʻaitiitia ai le lamatiaga o le thromboembolism.Mo tagata mamai hemodynamically le mautu ma fibrillation atrial e manaʻomia ai le faʻanatinati cardioversion, o le amataina o le anticoagulation e le tatau ona faʻatuai le cardioversion.Afai e leai se faʻalavelave, o le heparin poʻo le maualalo o le molecular weight heparin poʻo le NOAC e tatau ona faʻaaoga vave, ma e tatau ona faia le cardioversion i le taimi e tasi