Thrombin imatha kulimbikitsa kukomoka kwa magazi, imathandizira kuyimitsa magazi, komanso imathandizira kuchira kwa mabala ndi kukonza minofu.

Thrombin ndi chinthu chofunikira kwambiri pakupanga magazi, ndipo ndi puloteni yofunika kwambiri yomwe idasinthidwa kukhala fibrin mu fibrin.Mitsempha yamagazi ikawonongeka, glycrase imapangidwa pansi pa zochita za mapulateleti ndi ma cell endothelial cell, zomwe zimalimbikitsa kuphatikizika kwa mapulateleti ndi thrombosis, potero kuletsa hemostasis.Kuphatikiza apo, coordinase imathanso kulimbikitsa machiritso a zilonda ndi kukonza minofu, yomwe ndi chinthu chofunikira kwambiri cha enzyme pakukonzanso minofu.

Tikumbukenso kuti kwambiri kutsegula kwa thrombin kungayambitsenso mavuto monga thrombosis ndi matenda a mtima.Choncho, m`pofunika mosamalitsa kutsatira malangizo a dokotala ndi mlingo wa mankhwala ntchito coordinase - zokhudzana mankhwala kupewa chokhwima zochita ndi mavuto.

Ntchito ya fibrinogen poyambilira inali kulimbikitsa kuphatikizika kwa mapulateleti mu coagulation ya magazi.Fibrinogen poyambilira inali puloteni yofunika kwambiri munjira ya coagulation.Ntchito yake yaikulu ndi coagulation ndi hemostasis, ndi kutenga nawo mbali pakupanga mapulateleti.Mtengo wabwinobwino wa fibrinogen ndi 2-4g/L.Kukwera kwa mlingo woyambirira wa fibrin kumagwirizana kwambiri ndi kupezeka kwa matenda a thrombotic.Kuwonjezeka kwa kukwera kwa fibrin kungayambitsidwe ndi zinthu zakuthupi, monga kuchedwa kwa mimba ndi zaka, kapena zinthu za pathological, monga matenda oopsa, shuga, matenda a mtima a atherosclerotic.

Mlingo wa fibrin umachepa, womwe ukhoza kuyambitsidwa ndi matenda a chiwindi, monga matenda a cirrhosis ndi chiwindi chachikulu.Odwala amayenera kupita kuchipatala kukayezetsa nthawi yake ndikuwathandiza motsogozedwa ndi dokotala.