Kufunika kwachipatala
Ili ndi tanthauzo lofanana ndi nthawi ya coagulation, koma yokhala ndi chidwi chachikulu.Njira zambiri zodziwira za APTT zomwe zikugwiritsidwa ntchito panopa zingakhale zachilendo pamene plasma coagulation factor ndi yotsika kuposa 15% mpaka 30% ya mlingo wamba.
(1) Kutalikitsa kwa APTT: zotsatira za APTT ndi masekondi a 10 kuposa momwe zimakhalira nthawi zonse.APTT ndiye mayeso odalirika kwambiri owunika a endogenous coagulation factor deficiency ndipo amagwiritsidwa ntchito makamaka kuti apeze hemophilia yofatsa.Ngakhale factor Ⅷ: C milingo imatha kudziwika pansi pa 25% ya hemophilia A, kukhudzidwa kwa subclinical hemophilia (factor Ⅷ>25%) ndi onyamula hemophilia ndi osauka.Zotsatira za nthawi yayitali zimawonekeranso mu factor Ⅸ (hemophilia B), Ⅺ ndi Ⅶ zofooka;pamene magazi anticoagulant zinthu monga coagulation factor inhibitors kapena heparin misinkhu kuwonjezeka, prothrombin, fibrinogen ndi factor V, X akusowa Komanso Zitha kukhala yaitali, koma tilinazo pang'ono osauka;Kutalikitsa kwa APTT kungawonedwenso mwa odwala ena omwe ali ndi matenda a chiwindi, DIC, ndi kuchuluka kwa magazi osungidwa.
(2) Kufupikitsa kwa APTT: kumawoneka mu DIC, prethrombotic state ndi thrombotic matenda.
(3) Kuyang'anira chithandizo cha heparin: APTT imakhudzidwa kwambiri ndi kuchuluka kwa plasma heparin, kotero ndizomwe zimagwiritsidwa ntchito kwambiri pa labotale yowunikira pakali pano.Panthawiyi, ziyenera kudziwidwa kuti zotsatira za kuyeza kwa APTT ziyenera kukhala ndi ubale wofananira ndi kuchuluka kwa heparin mu plasma mumagulu achire, apo ayi sayenera kugwiritsidwa ntchito.Nthawi zambiri, panthawi ya chithandizo cha heparin, ndikofunikira kusunga APTT pa 1.5 mpaka 3.0 nthawi yanthawi zonse.
Kusanthula zotsatira
Zachipatala, APTT ndi PT nthawi zambiri zimagwiritsidwa ntchito ngati zoyesa zowunikira magazi.Malinga ndi miyeso, pali pafupifupi zinthu zinayi izi:
(1) APTT ndi PT zonse ndi zachilendo: Kupatula anthu wamba, zimangowoneka mu cholowa komanso chachiwiri cha FXIII.Zomwe zimapezeka ndizofala kwambiri m'matenda a chiwindi, chotupa cha chiwindi, malignant lymphoma, leukemia, anti-factor XIII antibody, autoimmune anemia ndi kuwonongeka kwa magazi.
(2) APTT yotalikirapo yokhala ndi PT yachibadwa: Matenda ambiri otaya magazi amayamba chifukwa cha zolakwika mu intrinsic coagulation pathway.Monga hemophilia A, B, ndi kusowa kwa factor Ⅺ;m'magazi muli ma anti-factor Ⅷ, Ⅸ, Ⅺ ma antibodies.
(3) APTT Yachibadwa yokhala ndi PT yotalikirapo: matenda ambiri a magazi omwe amayamba chifukwa cha zolakwika mu njira ya extrinsic coagulation, monga kuperewera kwa chibadwa ndi kupeza factor VII.Zomwe zimapezedwa ndizofala m'matenda a chiwindi, DIC, anti-factor VII antibodies m'magazi komanso ma anticoagulants amkamwa.
(4) Onse APTT ndi PT amakhala nthawi yayitali: matenda ambiri otaya magazi omwe amayamba chifukwa cha zolakwika munjira yodziwika bwino ya coagulation, monga kuperewera kwa chibadwa komanso kupeza chinthu X, V, II ndi I.Zomwe zimagulidwa zimawoneka makamaka mu matenda a chiwindi ndi DIC, ndipo zinthu X ndi II zikhoza kuchepetsedwa pamene anticoagulants pakamwa amagwiritsidwa ntchito.Kuphatikiza apo, pakakhala ma anti-factor X, anti-factor V ndi anti-factor II m'magazi, amatalikitsidwa molingana.Heparin ikagwiritsidwa ntchito kuchipatala, onse APTTT ndi PT amatalika molingana.