Thrombosis nthawi zambiri imayamba chifukwa cha kuwonongeka kwa ma cell endothelial amtima, kusayenda bwino kwa magazi, komanso kuchuluka kwa magazi.

1. Kuvulala kwa Endothelial cell cell: Vascular endothelial cell kuvulala ndizofunikira kwambiri komanso zomwe zimayambitsa mapangidwe a thrombus, omwe amapezeka kwambiri m'matenda a rheumatic ndi infective endocarditis, chilonda chachikulu cha atherosclerotic plaque, kuvulala koopsa kapena kutupa Malo ovulala a Venous, etc. Kuphatikiza apo, Pambuyo pa hypoxia, mantha, sepsis ndi endotoxin ya bakiteriya imayambitsa kuwonongeka kwakukulu kwa endothelial m'thupi lonse, kolajeni pansi pa endothelium imayambitsa ndondomeko ya coagulation, zomwe zimachititsa kuti intravascular coagulation, ndi thrombus mu microcirculation ya thupi lonse.

2. Kusayenda bwino kwa magazi: makamaka kumatanthauza kuchepa kwa magazi ndi kubadwa kwa eddies mukuyenda kwa magazi, ndi zina zotero. Zomwe zimayambitsidwa ndi coagulation factor ndi thrombin zimafika ndende yofunikira kuti ipangike m'deralo, zomwe zimathandiza kuti kupanga thrombus.Pakati pawo, mitsempha imakhala yovuta kwambiri ku thrombus, yomwe imakhala yofala kwambiri kwa odwala omwe ali ndi vuto la mtima, matenda aakulu komanso kupuma kwa bedi.Kuonjezera apo, magazi akuyenda mu mtima ndi mitsempha ndi mofulumira, ndipo sikophweka kupanga thrombus.Komabe, pamene magazi akuyenda kumanzere kwa atrium, aneurysm, kapena nthambi ya mtsempha wamagazi ndi pang'onopang'ono ndipo eddy panopa imapezeka pa mitral valve stenosis, imakhalanso yovuta ku thrombosis.

3. Kuchuluka kwa magazi coagulation: Nthawi zambiri, kuwonjezeka kwa mapulateleti ndi coagulation zinthu m'magazi, kapena kuchepa kwa ntchito ya fibrinolytic dongosolo, kumabweretsa hypercoagulable boma m'magazi, amene ambiri cholowa ndi anapeza hypercoagulable mayiko.

Kuphatikiza apo, kuchepa kwa magazi a venous kungayambitsenso.Malinga ndi kuzindikira kothandiza kwa matenda omwe munthu ali nawo, kupewa ndi kuchiza kwasayansi kungathe kukwaniritsidwa kuti athandizire kuchira.