Chifukwa chachikulu

1. Kuvulala kwamtima kwa endothelial
Vascular endothelial cell kuvulala ndi chinthu chofunikira kwambiri komanso chofala chomwe chimayambitsa mapangidwe a thrombus, ndipo amapezeka kwambiri mu rheumatic and infective endocarditis, zilonda zazikulu za atherosclerotic plaque, zoopsa kapena zotupa za arteriovenous kuvulala, etc. Palinso hypoxia, mantha, sepsis ndi bakiteriya. ma endotoxins omwe amayambitsa matenda osiyanasiyana amkati mthupi lonse.
Pambuyo kuvulala pakhungu, kolajeni pansi pa endothelium imayendetsa njira yolumikizirana, kuchititsa kufalikira kwa intravascular coagulation, komanso mawonekedwe a thrombus mu microcirculation ya thupi lonse.

2. Kusayenda bwino kwa magazi
Makamaka amatanthauza kuchepa kwa magazi ndi m'badwo wa eddies mu magazi, etc., ndi adamulowetsa coagulation zinthu ndi thrombin kufika ndende zofunika kuti coagulation m'dera, amene amathandiza kuti mapangidwe thrombus.Pakati pawo, mitsempha imakhala yovuta kwambiri ku thrombus, yomwe imakhala yofala kwambiri kwa odwala omwe ali ndi vuto la mtima, matenda aakulu komanso kupuma kwa bedi.Kuonjezera apo, magazi akuyenda mu mtima ndi mitsempha ndi mofulumira, ndipo sikophweka kupanga thrombus.Komabe, pamene magazi akuyenda kumanzere kwa atrium, aneurysm, kapena nthambi ya mtsempha wamagazi ndi pang'onopang'ono ndipo eddy panopa imapezeka pa mitral valve stenosis, imakhalanso yovuta ku thrombosis.

3. Kuchuluka kwa magazi coagulation
Nthawi zambiri, mapulateleti ndi ma coagulation m'magazi amawonjezeka, kapena ntchito ya fibrinolytic system imachepa, zomwe zimatsogolera ku hypercoagulable state m'magazi, omwe amapezeka kwambiri m'maiko obadwa nawo komanso omwe amapezeka ndi hypercoagulable.

4. Cholowa hypercoagulable boma
Zimagwirizana ndi cholowa coagulation factor zolakwika, kobadwa nako kupunduka kwa mapuloteni C ndi mapuloteni S, etc. Pakati pawo, chinthu chofala kwambiri V jini masinthidwe, mutation mlingo wa jini akhoza kufika 60% odwala ndi zinabadwa zakuya mtsempha thrombosis.

5. Anapeza hypercoagulable boma
Zomwe zimawonedwa mu khansa ya m'mapapo, khansa ya m'mapapo, khansa ya m'mawere, khansa ya prostate, khansa ya m'mimba ndi zotupa zina zowopsa kwambiri za metastatic, zomwe zimayambitsidwa ndi kutulutsidwa kwa zinthu za procoagulant ndi maselo a khansa;Zitha kuchitikanso pazovuta kwambiri, kutentha kwakukulu, opaleshoni yaikulu kapena pambuyo pobereka Pakatayika kwambiri magazi, komanso pamikhalidwe monga gestational hypertension, hyperlipidemia, coronary atherosclerosis, kusuta fodya, ndi kunenepa kwambiri.