Pansi pa zochitika za thupi, machitidwe awiri a magazi coagulation ndi anticoagulation m'thupi amakhalabe ndi mphamvu zowonongeka kuti magazi aziyenda m'mitsempha ya magazi.Ngati kusalinganika sikuli bwino, dongosolo la anticoagulation ndilofala ndipo chizolowezi chotaya magazi chimakonda kuchitika, ndipo dongosolo la coagulation ndilofala ndipo thrombosis imakonda kuchitika.Dongosolo la fibrinolysis limagwira ntchito yofunika kwambiri mu thrombolysis.Lero tikambirana za zizindikiro zina ziwiri za fibrinolysis system, D-dimer ndi FDP, kuti timvetse bwino hemostasis yopangidwa ndi thrombin ku thrombus yoyambitsidwa ndi fibrinolysis.Chisinthiko.Perekani zambiri zachipatala za odwala thrombosis ndi coagulation ntchito.
D-dimer ndi chinthu choyipa chomwe chimapangidwa ndi fibrin monomer yolumikizidwa ndi activated factor XIII kenako ndi hydrolyzed ndi plasmin.D-dimer imachokera ku mtanda wa fibrin clot wosungunuka ndi plasmin.Kukwera kwa D-dimer kumawonetsa kukhalapo kwa hyperfibrinolysis yachiwiri (monga DIC).FDP ndi mawu omwe amagwiritsidwa ntchito ponena za zinthu zowonongeka zomwe zimapangidwa pambuyo pa kusweka kwa fibrin kapena fibrinogen pogwiritsa ntchito plasmin yomwe imapangidwa panthawi ya hyperfibrinolysis.FDP imaphatikizapo zinthu za fibrinogen (Fg) ndi zinthu za fibrin monomer (FM) (FgDPs), komanso zinthu zowonongeka za fibrin (FbDPs), zomwe FbDPs imaphatikizapo ma D-dimers ndi zidutswa zina, ndipo milingo yawo imawonjezeka Kwambiri imasonyeza kuti thupi ntchito ya fibrinolytic ndi hyperactive (primary fibrinolysis kapena secondary fibrinolysis)
【Chitsanzo】
Mnyamata wina wazaka zapakati adagonekedwa m'chipatala ndipo zotsatira za kuyezetsa magazi kwamagazi zinali motere:
| Kanthu | Zotsatira | Reference Range |
| PT | 13.2 | 10-14s |
| APTT | 28.7 | 22-32s |
| TT | 15.4 | 14-21s |
| Mtengo wa FIB | 3.2 | 1.8-3.5g/l |
| DD | 40.82 | 0-0.55mg/I FEU |
| FDP | 3.8 | 0-5mg/l |
| AT-III | 112 | 75-125% |
Zinthu zinayi za coagulation zonse zinali zoipa, D-dimer inali yabwino, ndipo FDP inali yoipa, ndipo zotsatira zake zinali zotsutsana.Poyamba amaganiziridwa kuti ndi mbedza, chitsanzocho chinawunikidwanso ndi mayeso oyambira angapo ndi 1:10, zotsatira zake zinali motere:
| Kanthu | Choyambirira | 1:10 kuchepetsedwa | Reference Range |
| DD | 38.45 | 11.12 | 0-0.55mg/I FEU |
| FDP | 3.4 | Pansi pa malire apansi | 0-5mg/l |
Zitha kuwoneka kuchokera ku dilution kuti zotsatira za FDP ziyenera kukhala zachilendo, ndipo D-dimer siili yofananira pambuyo pa dilution, ndipo kusokoneza kumaganiziridwa.Musaphatikizepo hemolysis, lipemia, ndi jaundice ku mkhalidwe wa chitsanzo.Chifukwa cha zotsatira zosawerengeka za dilution, milandu yotereyi imatha kuchitika molumikizana ndi ma antibodies a heterophilic kapena rheumatoid factor.Yang'anani mbiri yachipatala ya wodwalayo ndikupeza mbiri ya nyamakazi ya nyamakazi.Laboratory Zotsatira za mayeso a RF factor zinali zapamwamba.Atatha kulankhulana ndi chipatala, wodwalayo adanenedwa ndikupereka lipoti.Pambuyo pake, wodwalayo analibe zizindikiro zokhudzana ndi thrombus ndipo adaweruzidwa kuti ndi zabodza za D-dimer.
【Chidule】
D-dimer ndi chizindikiro chofunikira cha kusapezeka kwa thrombosis.Ili ndi chidwi chachikulu, koma chofananiracho chimakhala chofooka.Palinso gawo lina la zinthu zabodza.Kuphatikizika kwa D-dimer ndi FDP kumatha kuchepetsa gawo la D- Pazabodza zabodza za dimer, pomwe zotsatira za labotale zikuwonetsa kuti D-dimer ≥ FDP, zigamulo zotsatirazi zitha kupangidwa pazotsatira za mayeso:
1. Ngati zikhalidwe ndizotsika (
2. Ngati zotsatira zake ndi zamtengo wapatali (> Kudula mtengo), fufuzani zinthu zomwe zimakhudza, pakhoza kukhala zosokoneza.Ndi bwino kuchita angapo dilution mayeso.Ngati zotsatira zake ndi zofananira, zowoneka bwino zimakhala zowoneka bwino.Ngati si mzere, zonyenga zabodza.Mutha kugwiritsanso ntchito reagent yachiwiri kuti mutsimikizire ndikulumikizana ndi chipatala munthawi yake.
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