Pali ma coagulation ndi anticoagulation machitidwe m'magazi a anthu.Nthawi zonse, awiriwa amakhalabe osinthasintha kuti atsimikizire kuti magazi amayenda bwino m'mitsempha, ndipo sangapange thrombus.Pankhani ya kuchepa kwa magazi, kusowa kwa madzi akumwa, ndi zina zotero, kutuluka kwa magazi kudzakhala pang'onopang'ono, magazi adzakhala okhazikika komanso owoneka bwino, ntchito ya coagulation idzakhala yoopsa kwambiri kapena ntchito ya anticoagulation idzafowoka, yomwe idzaphwanya izi. ndi kupanga anthu mu "thrombotic state".Thrombosis imatha kuchitika paliponse m'mitsempha yamagazi.Thrombosis imayenda ndi magazi m'mitsempha yamagazi.Ngati ikhalabe mumitsempha yaubongo ndikutsekereza magazi abwinobwino a mitsempha yaubongo, ndiye kuti cerebral thrombosis, yomwe imayambitsa sitiroko ya ischemic.Mitsempha yam'mitsempha yamtima imatha kuyambitsa infarction ya myocardial, kuphatikizanso, kutsika kwa mitsempha ya m'munsi, kutsika kwa venous thrombosis, ndi pulmonary embolism.

Thrombosis, ambiri a iwo adzakhala ndi zizindikiro zazikulu pa chiyambi choyamba, monga hemiplegia ndi aphasia chifukwa cha infarction ya ubongo;kwambiri precordial colic mu myocardial infarction;kupweteka pachifuwa chachikulu, dyspnea, hemoptysis chifukwa cha infarction yam'mapapo;Zingayambitse kupweteka m'miyendo, kapena kumverera kozizira ndi claudication yapakatikati.Mtima woopsa kwambiri, cerebral infarction ndi pulmonary infarction zingayambitsenso imfa yadzidzidzi.Koma nthawi zina palibe zizindikiro zoonekeratu, monga wamba deep mtsempha thrombosis m`munsi malekezero, kokha ng`ombe ndi zilonda ndi zosasangalatsa.Odwala ambiri amaganiza kuti ndi chifukwa cha kutopa kapena kuzizira, koma samachiganizira mozama, choncho n'zosavuta kuphonya nthawi yabwino yothandizira.N'zomvetsa chisoni kwambiri kuti madokotala ambiri amakonda kudwala molakwika.Pamene edema ya m'munsi mwake ichitika, sizidzangobweretsa zovuta kuchiza, komanso kusiya zovuta zina.