Thrombosis, kuphatikizapo 2 njira:

1. Kumamatira ndi kuphatikiza kwa mapulateleti m'magazi

Kumayambiriro kwa thrombosis, mapulateleti amayenda mosalekeza kuchokera ku axial otaya ndipo amamatira pamwamba pa ulusi wa collagen wowonekera pa intima ya mitsempha yowonongeka.Mapulateleti amayendetsedwa ndi collagen ndikutulutsa zinthu monga ADP, thromboxane A2, 5-AT ndi platelet factor IV., Zinthu zimenezi zimakhala ndi mphamvu yowonjezereka ya mapulateleti a agglutinating, kotero kuti mapulateleti a m’magazi akupitirizabe kuwunjikana m’deralo kupanga mulu wooneka ngati mulu., chiyambi cha venous thrombosis, mutu wa thrombus.

Mapulateleti amamatira pamwamba pa ulusi wowonekera wa collagen pa intima ya mtsempha wowonongeka wamagazi ndipo amayatsidwa kuti apange stack ngati hillock-ngati mapulateleti.Hillock pang'onopang'ono imakula ndikusakaniza ndi leukocyte kupanga thrombus yoyera.Ili ndi ma leukocyte ambiri omwe amamangiriridwa pamwamba pake.Kuthamanga kwa magazi pang'onopang'ono kumachepa, dongosolo la coagulation limatsegulidwa, ndipo kuchuluka kwa fibrin kumapanga dongosolo la network, lomwe limatseketsa maselo ofiira ambiri ndi maselo oyera a magazi kuti apange thrombus wosakanikirana.

2. Magazi coagulation

Pambuyo pakupanga thrombus yoyera, imatuluka mu lumen ya mitsempha, kuchititsa kuti magazi apite kumbuyo kwake achepetse ndikuwoneka ngati whirlpool, ndipo mulu watsopano wa platelet umapangidwa pa whirlpool.Ma trabeculae, opangidwa ngati ma coral, ali ndi ma leukocyte ambiri omwe amamangiriridwa pamwamba pake.

Kuthamanga kwa magazi pakati pa trabeculae kumachepetsa pang'onopang'ono, dongosolo la coagulation limatsegulidwa, ndipo kuchuluka kwa zinthu za coagulation m'deralo ndi zinthu za platelet kumawonjezeka pang'onopang'ono, kupanga ndi kuphatikizira muzitsulo zamtundu pakati pa trabeculae.White ndi woyera, malata wosanganiza thrombus kupanga thupi la thrombus.

Kuphatikizika kwa thrombus pang'onopang'ono kunakula ndikupitilira njira ya magazi, ndipo pamapeto pake kutsekereza lumen yamagazi, ndikupangitsa kuti magazi asiye.