Zinthu Zisanu ndi chimodzi Zidzakhudza Zotsatira Zakuyesa kwa Coagulation


Wolemba: Wolowa m'malo   

1. Makhalidwe a moyo

Zakudya (monga chiwindi cha nyama), kusuta, kumwa, etc. zidzakhudzanso kuzindikira;

2. Mankhwala Osokoneza Bongo

(1) Warfarin: makamaka imakhudza makhalidwe a PT ndi INR;
(2) Heparin: Imakhudza kwambiri APTT, yomwe imatha kutalika ndi 1.5 mpaka 2.5 nthawi (odwala omwe amathandizidwa ndi anticoagulant, yesetsani kusonkhanitsa magazi pambuyo poti ndende ya mankhwalawa yachepetsedwa kapena mankhwalawa adutsa theka la moyo);
(3) Maantibayotiki: Kugwiritsa ntchito mlingo waukulu wa maantibayotiki kungayambitse kutalika kwa PT ndi APTT.Zanenedwa kuti penicillin ikafika 20,000 u/ML m'magazi, PT ndi APTT zitha kukulitsidwa kupitilira nthawi imodzi, ndipo mtengo wa INR ukhoza kukulitsidwanso nthawi yopitilira 1 (Milandu ya coagulation yachilendo yoyambitsidwa ndi intravenous). (Nodoperazone-sulbactam)
(4) Thrombolytic mankhwala;
(5) Mankhwala a emulsion omwe amatumizidwa kunja amatha kusokoneza zotsatira za mayesero, ndipo centrifugation yothamanga kwambiri ingagwiritsidwe ntchito kuchepetsa kusokoneza pa nkhani ya magazi a lipid aakulu;
(6) Mankhwala monga aspirin, dipyridamole ndi ticlopidine amatha kuletsa kuphatikizika kwa mapulateleti;

3. Zinthu zosonkhanitsira magazi:

(1) Chiŵerengero cha sodium citrate anticoagulant ndi magazi nthawi zambiri chimakhala 1: 9, ndipo chimasakanizidwa bwino.Zanenedwa m'mabuku kuti kuwonjezeka kapena kuchepa kwa ndende ya anticoagulant kumakhudza kuzindikira ntchito ya coagulation.Pamene kuchuluka kwa magazi kumawonjezeka ndi 0,5 mL, nthawi yotseka imatha kufupikitsidwa;pamene kuchuluka kwa magazi kumachepa ndi 0,5 mL, nthawi yotseka imatha kukhala yayitali;
(2) Menyani msomali pamutu kuti mupewe kuwonongeka kwa minofu ndi kusakanikirana kwa zinthu zomwe zimatuluka kunja;
(3) Nthawi ya cuff sayenera kupitirira 1 min.Ngati khafu ikanikizidwa mwamphamvu kwambiri kapena nthawi yayitali kwambiri, factor VIII ndi tissue plasmin source activator (t-pA) zidzatulutsidwa chifukwa cha ligation, ndipo jekeseni wa magazi adzakhala wamphamvu kwambiri.Ndiwonso kuwonongeka kwa maselo amwazi komwe kumayambitsa dongosolo la coagulation.

4. Zotsatira za nthawi ndi kutentha za kuyika kwa zitsanzo:

(1) Zinthu za coagulation Ⅷ ndi Ⅴ ndizosakhazikika.Pamene nthawi yosungirako ikuwonjezeka, kutentha kosungirako kumawonjezeka, ndipo ntchito ya coagulation imachepa pang'onopang'ono.Choncho, chitsanzo cha magazi coagulation chiyenera kutumizidwa kuti chiwunikidwe mkati mwa ola la 1 mutatha kusonkhanitsa, ndipo mayeserowo ayenera kumalizidwa mkati mwa maola awiri kuti asapangitse PT., APTT kutalikitsa.(2) Pazitsanzo zomwe sizingadziwike munthawi yake, plasma iyenera kupatulidwa ndikusungidwa pansi pa chivindikiro ndikusungidwa mufiriji pa 2 ℃ ~ 8 ℃.

5. Zochepa / zovuta kwambiri za hemolysis ndi lipidemia zitsanzo

Zitsanzo za hemolyzed zili ndi coagulation ntchito yofanana ndi platelet factor III, yomwe ingafupikitse nthawi ya TT, PT, ndi APTT ya plasma ya hemolyzed ndikuchepetsa zomwe zili mu FIB.

6. Zina

Hypothermia, acidosis, ndi hypocalcemia zingayambitse thrombin ndi coagulation factor kukhala yosagwira ntchito.