Ofufuza ku yunivesite ya Monash apanga antibody yatsopano yomwe imatha kuletsa mapuloteni enaake m'magazi kuti ateteze thrombosis popanda zotsatirapo.Antibody imeneyi imatha kuteteza matenda a thrombosis, omwe angayambitse matenda a mtima ndi zikwapu popanda kusokoneza ntchito yotseka magazi.

Matenda a mtima ndi sitiroko ndizomwe zimayambitsa kufa komanso kudwala padziko lonse lapansi.Thandizo lamakono la antithrombotic (anticoagulant) lingayambitse mavuto aakulu otaya magazi chifukwa limasokonezanso kutsekeka kwa magazi.Odwala anayi mwa asanu mwa odwala omwe amalandila mankhwala a antiplatelet amakhalabe ndi zochitika zamtima zomwe zimachitika mobwerezabwereza.

Choncho, mankhwala omwe alipo a antiplatelet sangathe kugwiritsidwa ntchito pamlingo waukulu.Choncho, mphamvu zachipatala zikadali zokhumudwitsa, ndipo chithandizo chamtsogolo chiyenera kukonzedwanso.

Njira yofufuzira ndiyoyamba kudziwa kusiyana kwachilengedwe pakati pa coagulation yachibadwa ndi pathological coagulation, ndikupeza kuti von Willebrand factor (VWF) amasintha katundu wake pamene thrombus yoopsa ipangidwa.Kafukufukuyu adapanga antibody yomwe imangozindikira ndikutchinga mawonekedwe a VWF, chifukwa amangogwira ntchito pamene magazi atuluka.

Kafukufukuyu adasanthula mawonekedwe a ma anti-VWF omwe alipo ndipo adazindikira mikhalidwe yabwino kwambiri ya anti-antibody iliyonse kuti amange ndi kutsekereza VWF pansi pamikhalidwe ya pathological coagulation.Ngati palibe vuto lililonse, ma antibodies omwe angayambitse matendawa amayamba kuphatikizidwa m'magazi atsopano kuti apewe zovuta zomwe zingachitike.

Madokotala pakali pano akukumana ndi kusakhazikika bwino pakati pa mphamvu ya mankhwala ndi zotsatira zoyipa za magazi.Ma antibody opangidwa ndi makina opangidwa mwapadera ndipo sangasokoneze kuthamanga kwa magazi, kotero tikuyembekeza kuti atha kugwiritsa ntchito mlingo wapamwamba komanso wogwira mtima kuposa mankhwala omwe alipo kale.

Kafukufuku wa in vitro uyu adachitidwa ndi zitsanzo za magazi a anthu.Chotsatira ndikuyesa mphamvu ya antibody mu kachitsanzo kakang'ono kanyama kuti timvetsetse momwe imagwirira ntchito m'moyo wovuta wofanana ndi wathu.

Reference: Thomas Hoefer et al.Kutsata kukameta ubweya wa ubweya wopangidwa ndi von Willebrand factor ndi buku la single-chain antibody A1 kumachepetsa mapangidwe a thrombus mu vitro, Haematologica (2020).