Kuthamanga kwa magazi nthawi zambiri kulibe ngakhale zabwino kapena zoipa.Magazi coagulation ali ndi nthawi yokhazikika.Ngati ithamanga kwambiri kapena pang'onopang'ono, imakhala yovulaza thupi la munthu.

Magazi coagulation adzakhala m'gulu linalake wabwinobwino, kuti asayambitse magazi ndi thrombus mapangidwe mu thupi la munthu.Ngati magazi coagulation mofulumira kwambiri, izo nthawi zambiri zimasonyeza kuti thupi la munthu ali mu hypercoagulable boma, ndi mtima ndi cerebrovascular matenda sachedwa kuchitika, monga matenda infarction ndi Myocardial infarction, m`munsi malekezero venous thrombosis ndi matenda ena.Ngati magazi a wodwalayo akuundana pang’onopang’ono, n’kutheka kuti ali ndi vuto la coagulation, sachedwa kudwala matenda otaya magazi, monga hemophilia, ndipo zikavuta kwambiri, amatha kupunduka m’malo olumikizirana mafupa ndi zinthu zina zoipa.

Kuchita bwino kwa thrombin kumasonyeza kuti mapulateleti akugwira ntchito bwino komanso ali ndi thanzi labwino.Coagulation imatanthawuza kusinthika kwa magazi kuchokera kumalo oyenda kupita ku gel state, ndipo tanthauzo lake ndi njira yosinthira soluble fibrinogen kukhala insoluble fibrinogen mu plasma.M'njira yopapatiza, mitsempha yamagazi ikawonongeka, thupi limatulutsa zinthu zomwe zimapangitsa kuti magazi azilumikizana, zomwe zimasinthidwanso kuti zipange thrombin, yomwe pamapeto pake imasintha fibrinogen kukhala fibrin, motero imalimbikitsa kukomoka kwa magazi.Coagulation nthawi zambiri imaphatikizanso ntchito zamapulateleti.

Kuona ngati coagulation ndi yabwino kapena ayi, makamaka kudzera mu magazi ndi ma laboratory mayeso.Kusokonekera kwa coagulation kumatanthawuza zovuta za coagulation, kuchepa kwa kuchuluka kapena kusagwira bwino ntchito, komanso zizindikiro zingapo zamagazi.Kutaya magazi kodzidzimutsa kungachitike, ndipo pakhungu ndi pakhungu zimatha kuwoneka pakhungu ndi pakhungu.Pambuyo povulala kapena opaleshoni, kuchuluka kwa magazi kumawonjezeka ndipo nthawi yotaya magazi imatha kukhala yayitali.Kudzera kudziwika kwa prothrombin nthawi, pang`ono adamulowetsa prothrombin nthawi ndi zinthu zina, anapeza kuti coagulation ntchito si bwino, ndipo chifukwa cha matenda ayenera kumveka bwino.