Pamene wodwala coagulation bwino kumabweretsa magazi, mwina chifukwa cha kuchepa kwa coagulation ntchito.Kuyesa kwa coagulation factor ndikofunikira.N'zoonekeratu kuti magazi amayamba chifukwa cha kusowa kwa coagulation zinthu kapena zinthu zambiri anticoagulation.Malinga ndi zomwe zimayambitsa, onjezerani zomwe zikugwirizana ndi coagulation kapena plasma yatsopano.Kukhalapo kwa zinthu zambiri zomwe zimapangitsa kuti magazi aziundana zingathandize kuti magazi asiye kutuluka.Kachipatala, zitha kuzindikirika ngati zinthu zomwe zikugwirizana ndi coagulation zamkati ndi kunja kwa coagulation njira za coagulation zimachepetsedwa kapena zimasokonekera, ndikuwona ngati vuto la coagulation limayamba chifukwa cha kusowa kwa coagulation factor kapena ntchito ya coagulation factor, makamaka. kuphatikiza zinthu izi:

1. Njira yowonongeka ya endogenous coagulation: Chinthu chachikulu cha coagulation chomwe chimakhudza njira ya endogenous coagulation ndi APTT.Ngati APTT ikutalika, zikutanthauza kuti pali zovuta zowonongeka mu njira yowonongeka, monga factor 12, factor 9, factor 8, and common pathway 10. Kuperewera kwa zinthu kungayambitse zizindikiro za magazi kwa odwala;

2. Njira yosadziwika bwino yotuluka kunja: ngati PT ikutalika, imatha kudziwika kuti minofu, factor 5 ndi factor 10 mu njira yodziwika bwino ingakhale yachilendo, ndiko kuti, kuchepa kwa chiwerengero kumabweretsa nthawi yaitali ya coagulation ndikuyambitsa magazi. mwa wodwala.