Pakachitika vuto la coagulation, kuyezetsa magazi ndi kuyezetsa magazi kuyenera kuchitika kaye, ndipo ngati kuli kofunikira, kuyezetsa kwamafuta a m'mafupa kuyenera kuchitidwa kuti kumveketse chomwe chimayambitsa kukomoka, ndiyeno chithandizo choyenera chiyenera kuchitidwa.

1. Thrombocytopenia
Essential thrombocytopenia ndi matenda a autoimmune omwe amafunikira kugwiritsa ntchito glucocorticoids, gamma globulin pochiza immunosuppressive, komanso kugwiritsa ntchito ma androgens kulimbikitsa hematopoiesis.Thrombocytopenia chifukwa cha hypersplenism imafuna splenectomy.Ngati thrombocytopenia ndi yoopsa, kuletsa ntchito kumafunika, ndipo kuikidwa magazi kumachepetsa magazi ambiri.

2. Kuperewera kwa coagulation factor
Hemophilia ndi matenda obadwa nawo otaya magazi.Thupi silingathe kupanga coagulation factor 8 ndi 9, ndipo magazi amatha kuchitika.Komabe, palibe mankhwala ochiza matendawa, ndipo zinthu zomwe zimayambitsa coagulation zitha kuwonjezeredwa kuti zitheke.Mitundu yosiyanasiyana ya hepatitis, cirrhosis ya chiwindi, khansa ya chiwindi ndi ntchito zina zachiwindi zimawonongeka ndipo sizingaphatikize zinthu zokwanira za coagulation, kotero chithandizo chachitetezo cha chiwindi chimafunika.Ngati vitamini K akusowa, magazi amatuluka, ndipo vitamini K yowonjezera imafunikanso kuchepetsa chiopsezo chotaya magazi.

3. Kuwonjezeka kwa makoma a mitsempha ya magazi
Kuwonjezeka kwa permeability kwa khoma la mtsempha wamagazi chifukwa cha zifukwa zosiyanasiyana kudzakhudzanso ntchito ya coagulation.M`pofunika kumwa mankhwala monga vitamini C kusintha permeability wa mitsempha.