M'moyo, anthu amangokhalira kugunda ndikutuluka magazi nthawi ndi nthawi.M’mikhalidwe yabwinobwino, ngati zilonda zina sizinachiritsidwe, mwaziwo umasweka pang’onopang’ono, kuleka kukhetsa mwazi wokha, ndipo m’kupita kwa nthaŵi kumachoka m’mitsempha ya mwazi.Chifukwa chiyani izi?Ndi zinthu ziti zomwe zathandiza kwambiri pankhaniyi?Kenako, tiyeni tifufuze chidziwitso cha magazi coagulation pamodzi!

Monga tonse tikudziwira, magazi amayenda nthawi zonse m'thupi la munthu pansi pa kukankhira kwa mtima kunyamula mpweya, mapuloteni, madzi, electrolytes ndi chakudya chofunikira m'thupi.Nthawi zonse, magazi amayenda m'mitsempha.Mitsempha yamagazi ikawonongeka, thupi limasiya kutulutsa magazi ndikuundana kudzera muzochita zingapo.Kuchulukana kwabwinobwino kwa thupi la munthu kumadalira kwambiri momwe khoma lamtsempha wamagazi limapangidwira komanso momwe zimagwirira ntchito, momwe zimakhalira komanso kuchuluka kwa mapulateleti ogwira mtima.

Nthawi zonse, mapulateleti amapangidwa m'kati mwa makoma a capillaries kuti asunge umphumphu wa makoma a mitsempha ya magazi.Mitsempha yamagazi ikawonongeka, kutsekemera kumachitika poyamba, kupanga makoma a mitsempha ya magazi mu gawo lowonongeka pafupi ndi mzake, kuchepetsa chilonda ndi kuchepetsa kuthamanga kwa magazi.Pa nthawi yomweyi, mapulateleti amamatira, amaphatikizana ndikutulutsa zomwe zili pagawo lowonongeka, ndikupanga thrombus wamba, kutsekereza bala.Hemostasis ya mitsempha ya magazi ndi mapulateleti amatchedwa hemostasis yoyamba, ndipo njira yopangira fibrin clot pamalo ovulala pambuyo poyambitsa dongosolo la coagulation kuti atseke chilondacho amatchedwa secondary hemostatic mechanism.

Mwachindunji, coagulation ya magazi imatanthawuza njira yomwe magazi amasintha kuchoka kumalo oyenda kupita ku gel osayenda.Coagulation zikutanthauza kuti zinthu zingapo coagulation amalowetsedwa motsatizana ndi enzymolysis, ndipo potsiriza thrombin amapangidwa kupanga fibrin kuundana.The coagulation process nthawi zambiri imakhala ndi njira zitatu, endogenous coagulation pathway, exogenous coagulation njira ndi wamba coagulation njira.

1) The endogenous coagulation njira imayambitsidwa ndi coagulation factor XII kudzera munjira yolumikizana.Kupyolera mu kutsegula ndi kuchitapo kanthu kwa zinthu zosiyanasiyana za coagulation, prothrombin imasandulika kukhala thrombin.Thrombin amasintha fibrinogen kukhala fibrin kuti akwaniritse cholinga chophatikiza magazi.

2) Njira yakunja ya coagulation imatanthawuza kutulutsidwa kwa minofu yake, yomwe imafuna nthawi yochepa kuti ipangike ndikuyankha mwachangu.

Kafukufuku wasonyeza kuti endogenous coagulation njira ndi exogenous coagulation njira akhoza adamulowetsa ndi onse awiri adamulowetsa.

3) Njira wamba ya coagulation imatanthawuza gawo la coagulation wamba wa endogenous coagulation system ndi exogenous coagulation system, yomwe makamaka imaphatikizapo magawo awiri a thrombin generation ndi fibrin mapangidwe.

Otchedwa hemostasis ndi magazi chotengera kuwonongeka, amene imayendetsa exogenous coagulation njira.Physiological ntchito ya endogenous coagulation njira pakali pano sizidziwika bwino.Komabe, ndi zowona kuti njira ya endogenous blood coagulation njira imatha kuyambitsidwa thupi la munthu likakumana ndi zinthu zopanga, zomwe zikutanthauza kuti zinthu zachilengedwe zimatha kuyambitsa magazi m'thupi la munthu, ndipo chodabwitsachi chakhalanso cholepheretsa kuikidwa kwa zipangizo zamankhwala m’thupi la munthu.

Zolakwika kapena zopinga zilizonse mu coagulation factor kapena ulalo wa coagulation zingayambitse zovuta kapena kusokonekera munjira yonse ya coagulation.Zitha kuwoneka kuti kutsekeka kwa magazi ndizovuta komanso zovuta m'thupi la munthu, zomwe zimagwira ntchito yofunika kwambiri kuti tisunge moyo wathu.