Pambuyo pa thrombosis, mapangidwe ake amasintha pansi pa machitidwe a fibrinolytic system ndi kugwedezeka kwa magazi ndi kusinthika kwa thupi.
Pali mitundu itatu yayikulu yosintha komaliza mu thrombus:
1. Kufewetsa, sungunula, kuyamwa
Pambuyo pakupanga thrombus, fibrin mmenemo imatenga madzi ambiri a plasmin, kotero kuti fibrin mu thrombus imakhala polypeptide yosungunuka ndikusungunuka, ndipo thrombus imafewetsa.Nthawi yomweyo, chifukwa ma neutrophils mu thrombus amasweka ndikutulutsa ma enzymes a proteolytic, thrombus imathanso kusungunuka ndikufewetsa.
The thrombus yaing'ono imasungunuka ndi kusungunuka, ndipo imatha kuyamwa kwathunthu kapena kutsukidwa ndi magazi popanda kusiya chizindikiro.
Mbali yaikulu ya thrombus imafewetsa ndipo imagwa mosavuta ndi kutuluka kwa magazi kuti ikhale embolus.Emboli imalepheretsa chotengera chamagazi chofananira ndi kutuluka kwa magazi, zomwe zingayambitse embolism, pomwe gawo lotsala limapangidwa.
2. Makina ndi Recanalization
Thrombi yaikulu sizovuta kusungunuka ndi kuyamwa kwathunthu.Kawirikawiri, mkati mwa masiku awiri kapena atatu pambuyo pa mapangidwe a thrombus, minofu ya granulation imakula kuchokera ku intima yowonongeka kumene thrombus imamangiriridwa, ndipo pang'onopang'ono imalowa m'malo mwa thrombus, yomwe imatchedwa bungwe la thrombus.
Pamene thrombus imakonzedwa, thrombus imachepa kapena imasungunuka pang'ono, ndipo mng'alu umapangidwa nthawi zambiri mkati mwa thrombus kapena pakati pa thrombus ndi khoma la chotengera, ndipo pamwamba pake amaphimbidwa ndi kuchuluka kwa mitsempha ya endothelial maselo, ndipo pamapeto pake mitsempha imodzi kapena ingapo yaing'ono yamagazi. zomwe zimalumikizana ndi mtsempha woyambirira wamagazi zimapangidwa.Kukonzanso kwa magazi kumatchedwa recanalization ya thrombus.
3. Kuwerengetsa
Chiwerengero chochepa cha thrombi chomwe sichikhoza kusungunuka kwathunthu kapena kukonzedwa chikhoza kusungunuka ndi kuwerengedwa ndi mchere wa calcium, kupanga miyala yolimba yomwe imakhalapo m'mitsempha ya magazi, yotchedwa phleboliths kapena arterioliths.
Zotsatira za magazi kuundana pathupi
Thrombosis imakhala ndi zotsatira ziwiri pathupi.
1. Kumbali yabwino
Thrombosis imapangidwa pamitsempha yamagazi, yomwe imakhala ndi hemostatic effect;thrombosis ya mitsempha yaing'ono yamagazi mozungulira foci yotupa imatha kuletsa kufalikira kwa mabakiteriya owopsa ndi poizoni.
2. Pansi
Mapangidwe a thrombus mu chotengera cha magazi angalepheretse chotengera cha magazi, kuchititsa minofu ndi chiwalo ischemia ndi infarction;
Thrombosis imapezeka pa valve ya mtima.Chifukwa cha bungwe la thrombus, valavu imakhala hypertrophic, shrunken, amamatira, ndi kuumitsa, chifukwa cha matenda a mtima wa valvular ndikukhudza ntchito ya mtima;
Thrombus ndi yosavuta kugwa ndi kupanga embolus, yomwe imayenda ndi magazi ndipo imapanga embolism m'madera ena, zomwe zimapangitsa kuti infarction iwonongeke;
Kuchuluka kwa microthrombosis mu microcirculation kumatha kuyambitsa kukha magazi kwakukulu komanso kugwedezeka.
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