Pa mimba yabwinobwino, kutulutsa kwa mtima kumawonjezeka ndipo kukana kwa zotumphukira kumachepa pakuwonjezeka kwa msinkhu wa gestational.Amakhulupirira kuti mtima umayamba kuwonjezeka pa masabata 8 mpaka 10 omwe ali ndi pakati, ndipo amafika pachimake pa masabata 32 mpaka 34 a mimba, omwe ndi 30% mpaka 45% apamwamba kuposa omwe alibe mimba, ndipo amakhalabe mpaka pano. kutumiza.Kutsika kwa zotumphukira mtima kukana kumachepetsa kuthamanga kwa magazi, ndipo kuthamanga kwa magazi kwa diastolic kumachepa kwambiri, ndipo kusiyana kwa kugunda kwa mtima kumakulirakulira.Kuyambira masabata 6 mpaka 10 a bere, kuchuluka kwa magazi kwa amayi apakati kumawonjezeka ndi kuwonjezeka kwa msinkhu, ndipo kumawonjezeka pafupifupi 40% kumapeto kwa mimba, koma kuwonjezeka kwa madzi a m'magazi kumaposa chiwerengero cha maselo ofiira a m'magazi, plasma. imawonjezeka ndi 40% mpaka 50%, ndipo maselo ofiira amawonjezeka ndi 10% mpaka 15%.Choncho, mu mimba yachibadwa, magazi amachepetsedwa, kuwonetseredwa ngati kuchepa kwa kukhuthala kwa magazi, kuchepa kwa hematocrit, ndi kuwonjezeka kwa erythrocyte sedimentation rate [1].

Magazi a coagulation factor Ⅱ, Ⅴ, VII, Ⅷ, IX, ndi Ⅹ onse amawonjezeka pa nthawi ya mimba, ndipo amatha kufika 1.5 mpaka 2.0 nthawi zachilendo pakati ndi mochedwa mimba, ndi ntchito za coagulation factor Ⅺ ndi  kuchepa.Fibrinopeptide A, fibrinopeptide B, thrombinogen, platelet factor Ⅳ ndi fibrinogen zinawonjezeka kwambiri, pamene antithrombin Ⅲ ndi mapuloteni C ndi mapuloteni S anachepa.Pa nthawi ya mimba, nthawi ya prothrombin ndi nthawi yowonjezera ya prothrombin imafupikitsidwa, ndipo plasma fibrinogen zomwe zili mu plasma zimawonjezeka kwambiri, zomwe zingathe kuwonjezeka kufika 4-6 g/L mu trimester yachitatu, yomwe ili pafupifupi 50% kuposa ya omwe alibe. nthawi.Kuonjezera apo, plasminogen inawonjezeka, nthawi ya kusungunuka kwa euglobulin inali yaitali, ndipo kusintha kwa coagulation-anticoagulation kunapangitsa kuti thupi likhale la hypercoagulable state, zomwe zinali zopindulitsa ku hemostasis yogwira mtima pambuyo pa kutuluka kwa placenta panthawi yobereka.Komanso, zinthu zina hypercoagulable pa mimba monga kuchuluka kwa mafuta m`thupi okwana, phospholipids ndi triacylglycerols m`mwazi, androgen ndi progesterone opangidwa ndi latuluka amachepetsa zotsatira za magazi coagulation inhibitors, latuluka, uterine decidua ndi miluza.Kukhalapo kwa zinthu za thromboplastin, ndi zina zotero, kungapangitse magazi kukhala mu hypercoagulable state, ndipo kusintha kumeneku kumawonjezereka ndi kuwonjezeka kwa msinkhu wa gestational.Moderate hypercoagulation ndi njira yotetezera thupi, yomwe imakhala yopindulitsa kusunga fibrin m'mitsempha, khoma la chiberekero ndi placenta villi, kuthandizira kusunga umphumphu wa placenta ndikupanga thrombus chifukwa cha kuvula, ndikuthandizira kuthamanga kwa magazi panthawi ndi pambuyo pobereka., ndi njira yofunika kwambiri yopewera kutaya magazi pambuyo pobereka.Pa nthawi yomweyo coagulation, sekondale fibrinolytic ntchito imayambanso kuchotsa thrombus mu uterine ozungulira mitsempha ndi venous nkusani ndi imathandizira kusinthika ndi kukonza endometrium [2].

Komabe, hypercoagulable state ingayambitsenso zovuta zambiri zoberekera.M'zaka zaposachedwapa, kafukufuku wapeza kuti amayi ambiri oyembekezera amakhala ndi thrombosis.Izi matenda mkhalidwe thromboembolism amayi apakati chifukwa cha chibadwa chilema kapena anapeza chiopsezo zinthu monga anticoagulant mapuloteni, coagulation zinthu, ndi fibrinolytic mapuloteni amatchedwa thrombosis.(thrombophilia), yomwe imadziwikanso kuti prothrombotic state.Izi sizimayambitsa matenda a thrombotic, koma zingayambitse zotsatira za mimba chifukwa cha kusalinganika kwa njira za coagulation-anticoagulation kapena ntchito ya fibrinolytic, microthrombosis ya uterine spiral arteries kapena villus, zomwe zimapangitsa kuti placenta isawonongeke kapena ngakhale infarction, monga Preeclampsia. , kutuluka kwa placenta, infarction ya placenta, disseminated intravascular coagulation (DIC), kuletsa kukula kwa fetal, kupita padera mobwerezabwereza, kubereka mwana wosabadwa ndi kubadwa msanga, ndi zina zotero, zingayambitse imfa ya amayi ndi obereketsa panthawi yovuta kwambiri.