Thrombosis nthawi zambiri imakhala ndi zinthu zitatu izi:

1. Mtima ndi mtsempha wamagazi kuvulala kwa intima

Kulumikizana kwamtima wabwinobwino ndi mitsempha yamagazi kumakhala kosalala komanso kosalala, ndipo ma cell a endothelial omwe amatha kuletsa kumamatira kwa mapulateleti ndi anticoagulation.Pamene nembanemba wamkati wawonongeka, dongosolo la coagulation likhoza kutsegulidwa m'njira zambiri.

Intima yoyamba yowonongeka imatulutsa minofu coagulation factor (coagulation factor III), yomwe imayambitsa kutuluka kwa coagulation system.
Kachiwiri, intima ikawonongeka, ma cell a endothelial amawonongeka, necrosis, ndi kukhetsa, kuwonetsa ulusi wa kolajeni pansi pa endothelium, potero kuyambitsa coagulation factor XII ya endogenous coagulation system ndikuyambitsa amkati coagulation system.Kuphatikiza apo, intima yowonongeka imakhala yovuta, yomwe imapangitsa kuti mapulateleti apangidwe ndi kumamatira.Mapulateleti otsatiridwa atatha kupasuka, zinthu zosiyanasiyana zamapulateleti zimatulutsidwa, ndipo njira yonse ya coagulation imayendetsedwa, zomwe zimapangitsa kuti magazi azilumikizana ndikupanga thrombus.
Zosiyanasiyana thupi, mankhwala ndi kwachilengedwenso zinthu zingachititse kuwonongeka kwa mtima intima, monga endocarditis mu nkhumba erysipelas, m`mapapo mwanga vasculitis mu bovine chibayo, equine parasitic arteritis, mobwerezabwereza jakisoni mu gawo lomwelo la mtsempha, Kuvulala ndi puncture wa khoma chotengera cha magazi. panthawi ya opaleshoni.

2. Kusintha kwa kayendedwe ka magazi

Makamaka amatanthauza kuyenda pang'onopang'ono kwa magazi, mapangidwe a vortex ndi kutha kwa magazi.
Nthawi zonse, kuthamanga kwa magazi kumakhala kofulumira, ndipo maselo ofiira a magazi, mapulateleti ndi zigawo zina zimayikidwa pakati pa mitsempha ya magazi, yomwe imatchedwa axial flow;pamene magazi akuyenda pang'onopang'ono, maselo ofiira a magazi ndi mapulateleti amayenda pafupi ndi khoma la mitsempha ya magazi, yotchedwa side flow, yomwe imawonjezera thrombosis.chiopsezo chomwe chimabwera.
Kuthamanga kwa magazi kumachepa, ndipo maselo a endothelial amakhala ndi hypoxic kwambiri, zomwe zimayambitsa kuwonongeka ndi necrosis ya maselo a endothelial, kutaya kwa ntchito yawo ya synthesizing ndi kumasula zinthu za anticoagulant, ndi kuwonetseredwa kwa collagen, yomwe imayambitsa dongosolo la coagulation ndi kulimbikitsa. thrombosis.
Kuthamanga kwa magazi pang'onopang'ono kungapangitsenso kuti thrombus yopangidwa ikhale yosavuta kukonza pakhoma la mitsempha ya magazi ndikupitiriza kuwonjezeka.

Chifukwa chake, thrombus nthawi zambiri imapezeka m'mitsempha yoyenda pang'onopang'ono komanso yomwe imakhala ndi mafunde a eddy (pa mavavu a venous).Kuthamanga kwa magazi kumayenda mofulumira, ndipo thrombus sichiwoneka kawirikawiri.Malinga ndi ziwerengero, kupezeka kwa venous thrombosis ndi 4 kuwirikiza kawiri kuposa kwa arterial thrombosis, ndipo venous thrombosis nthawi zambiri imachitika pakulephera kwa mtima, pambuyo pa opaleshoni kapena nyama zodwala zomwe zagona pachisa kwa nthawi yayitali.
Chifukwa chake, ndikofunikira kwambiri kuthandiza nyama zodwala zomwe zagona kwa nthawi yayitali komanso pambuyo pa opaleshoni kuti zithandizire kupewa thrombosis.
3. Kusintha kwa magazi.

Makamaka amatanthauza kuchuluka magazi coagulation.Monga amayaka kwambiri, kuchepa madzi m'thupi, etc. kuika magazi, zoopsa zoopsa, postpartum, ndi kutaya magazi kwambiri pambuyo ntchito yaikulu akhoza kuonjezera chiwerengero cha othandiza magazi kuundana m'magazi, kuonjezera kukhuthala kwa magazi, ndi kuonjezera zili fibrinogen, thrombin ndi zinthu zina coagulation. Kuwonjezeka kwa plasma.Zinthu izi zimatha kuyambitsa thrombosis.