Thupi labwinobwino limakhala ndi dongosolo lathunthu la coagulation ndi anticoagulation.Dongosolo la coagulation ndi anticoagulation system imakhalabe yokhazikika kuti iwonetsetse kuti magazi akuyenda bwino komanso kuyenda bwino kwa magazi.Pamene coagulation ndi anticoagulation ntchito bwino kusokonezeka, zimabweretsa magazi ndi thrombosis chizolowezi.

1. Thupi limagwira ntchito ngati coagulation

Dongosolo la coagulation limapangidwa makamaka ndi zinthu zomwe zimapangidwira.Zinthu zomwe zimakhudzidwa mwachindunji ndi coagulation zimatchedwa coagulation factor.Pali zinthu 13 zodziwika bwino za coagulation.

Pali amkati kutsegula njira ndi exogenous kutsegula njira kwa kutsegula kwa coagulation zinthu.

Pakali pano akukhulupirira kuti kutsegula kwa exogenous coagulation dongosolo anayambitsa ndi minofu factor amatenga mbali yaikulu pa kuyambitsa coagulation.Kugwirizana kwapafupi pakati pa machitidwe a mkati ndi kunja kwa coagulation kumagwira ntchito yofunika kwambiri poyambitsa ndi kusunga ndondomeko ya coagulation.

2. Ntchito ya m'thupi ya anticoagulant

Anticoagulation system imaphatikizapo ma cell anticoagulation system ndi anticoagulation system yamadzimadzi amthupi.

①Ma cell anticoagulation system

Amatanthauza phagocytosis wa coagulation factor, minofu chinthu, prothrombin zovuta ndi sungunuka fibrin monoma ndi mononuclear-phagocyte dongosolo.

②Body fluid anticoagulation system

Kuphatikizapo: serine protease inhibitors, mapuloteni C-based protease inhibitors ndi minofu factor pathway inhibitors (TFPI).

3. Fibrinolytic dongosolo ndi ntchito zake

Makamaka plasminogen, plasmin, plasminogen activator ndi fibrinolysis inhibitor.

Udindo wa fibrinolytic dongosolo: Sungunulani fibrin kuundana ndi kuonetsetsa kumayenda bwino kwa magazi;kutenga nawo mbali pakukonza minofu ndi kusinthika kwa mitsempha.

4. Udindo wa ma cell endothelial cell mu njira ya coagulation, anticoagulation ndi fibrinolysis.

① Kupanga zinthu zosiyanasiyana zogwira ntchito mwachilengedwe;

②Kuwongolera magazi coagulation ndi anticoagulation ntchito;

③Sinthani ntchito ya fibrinolysis system;

④ Kuwongolera kuthamanga kwa mtima;

⑤Kutenga nawo mbali pakuyimira pakati pa kutupa;

⑥Sungani ntchito ya microcirculation, etc.

Matenda a coagulation ndi anticoagulant

1. Zolakwika muzinthu zomwe zimapangitsa kuti thupi liziyenda bwino.

2. Kusakhazikika kwa zinthu za anticoagulant mu plasma.

3. Kusakhazikika kwa fibrinolytic factor mu plasma.

4. Kusakhazikika kwa maselo amwazi.

5. Mitsempha yosadziwika bwino.