Nthawi ya Prothrombin (PT) ndi chizindikiro chofunikira kwambiri chowonetsera ntchito ya kaphatikizidwe kachiwindi, kusungitsa ntchito, kuuma kwa matenda komanso momwe zimakhalira.Pakalipano, chidziwitso chachipatala cha coagulation factor chakhala chenicheni, ndipo chidzapereka chidziwitso choyambirira komanso cholondola kuposa PT poweruza matenda a chiwindi.

Kugwiritsa ntchito kwachipatala kwa PT mu matenda a chiwindi:

Laboratory imafotokoza PT m'njira zinayi: prothrombintime activitypercentagePTA (prothrombin time ratio PTR) ndi international normalized ratio INR.Mafomu anayiwa ali ndi zosiyana zogwiritsira ntchito zachipatala.

Kufunika kwa PT mu matenda a chiwindi: PT imatsimikiziridwa makamaka ndi mlingo wa coagulation factor IIvX wopangidwa ndi chiwindi, ndipo ntchito yake mu matenda a chiwindi ndi yofunika kwambiri.Mlingo wachilendo wa PT mu pachimake matenda a chiwindi anali 10% -15%, matenda a chiwindi anali 15% -51%, matenda enaake anali 71%, ndi aakulu chiwindi - 90%.Mu njira matenda a tizilombo chiwindi mu 2000, PTA ndi chimodzi mwa zizindikiro za matenda staging odwala ndi tizilombo chiwindi.Matenda tizilombo chiwindi odwala wofatsa PTA>70%, zolimbitsa 70% -60%, kwambiri 60% -40%;matenda enaake ndi chipukuta siteji PTA> 60% decompensated siteji PTA <60%;kwambiri chiwindi cha chiwindi PTA <40%" Mu gulu Child-Pugh, 1 mfundo PT kutalikitsa 1 ~ 4s, 2 mfundo 4 ~ 6s, 3 mfundo > 6s, pamodzi ndi zizindikiro zina 4 (albumin, bilirubin, ascites, encephalopathy ), ntchito ya chiwindi ya odwala omwe ali ndi matenda a chiwindi Zosungirako zimagawidwa m'magulu a ABC; chiwerengero cha MELD (Modelfor end-stageliver disease), chomwe chimatsimikizira kuopsa kwa matendawa kwa odwala omwe ali ndi matenda a chiwindi otsiriza komanso ndondomeko ya kuyika chiwindi, chilinganizo ndi .8xloge[bilirubin(mg/dl)+11.2xloge(INR)+ 9.6xloge[creatinine (mg/dl]+6.4x (chifukwa: biliary kapena mowa 0; zina 1), INR ndi chimodzi mwa zizindikiro zitatu.

Njira zodziwira matenda a DIC za matenda a chiwindi ndi: PT kutalika kwa nthawi yoposa 5s kapena activated partial thromboplastin time (APTT) kwa zaka zoposa 10, factor VIII ntchito <50% (yofunika);PT ndi mapulateleti nthawi zambiri amagwiritsidwa ntchito poyesa chiwopsezo cha chiwindi ndi opaleshoni Chizoloŵezi cha magazi cha odwala, monga mapulateleti <50x10 °/L, ndi kutalika kwa PT kuposa nthawi zonse kwa 4s ndizotsutsana ndi chiwindi cha chiwindi ndi opaleshoni kuphatikizapo kuyika chiwindi.Zitha kuwoneka kuti PT imagwira ntchito yofunika kwambiri pozindikira komanso kuchiza odwala omwe ali ndi matenda a chiwindi.