The main difference between blood agglutination and blood coagulation is that blood agglutination refers to the aggregation of red blood cells and platelets in the blood into blocks under external stimulation, while blood coagulation refers to the formation of a coagulation network by coagulation factors in the blood through a series of enzymatic reactions.

1. Blood agglutination is a rapid and reversible process mainly formed by the aggregation of red blood cells and platelets, usually occurring under stimuli such as trauma or inflammation. Blood coagulation is a slow and irreversible process that mainly forms a coagulation network through a series of complex thrombin catalyzed reactions, usually occurring during vascular injury.

2.The main purpose of blood agglutination is to form blood clots to prevent bleeding. The main purpose of blood coagulation is to form blood clots at the site of vascular injury, repair blood vessels, and stop bleeding.

3. Blood coagulation mainly involves the aggregation of red blood cells and platelets, while blood coagulation mainly involves the activation and aggregation of coagulation factors, enzymes, and fibrinogen in plasma.

4.During the process of blood aggregation, the thrombus formed by the aggregation of red blood cells and platelets is relatively loose and prone to rupture. During the process of blood coagulation, the fibrin clots formed are relatively stable and difficult to rupture.

5. Blood coagulation usually occurs at the site of trauma or inflammation, while blood coagulation typically occurs inside blood vessels, especially on damaged vessel walls.

It should be noted that blood aggregation and blood coagulation are two related but different physiological processes. The disorder of blood coagulation and coagulation may lead to diseases such as bleeding or thrombosis, so studying its mechanisms is of great clinical significance.