APTT stands for activated partial thromboplastin time, which refers to the time required to add partial thromboplastin to the tested plasma and observe the time required for plasma coagulation. APTT is a sensitive and most commonly used screening test for determining the endogenous coagulation system. The normal range is 31-43 seconds, and 10 seconds more than the normal control has clinical significance. Due to the differences among individuals, if the degree of APTT shortening is very slight, it may also be a normal phenomenon, and there is no need to be overly nervous, and regular reexamination is enough. If you feel unwell, see a doctor in time.

APTT shortening indicates that the blood is in a hypercoagulable state, which is common in cardiovascular and cerebrovascular thrombotic diseases, such as cerebral thrombosis and coronary heart disease.

1. Cerebral thrombosis

Patients with significantly shortened APTT are more likely to develop cerebral thrombosis, which is common in diseases related to blood hypercoagulation caused by changes in blood components, such as hyperlipidemia. At this time, if the degree of cerebral thrombosis is relatively mild, only symptoms of insufficient blood supply to the brain will appear, such as dizziness, headache, nausea, and vomiting. If the degree of cerebral thrombosis is severe enough to cause severe cerebral parenchymal ischemia, clinical symptoms such as ineffective limb movement, speech impairment, and incontinence will appear. For patients with acute cerebral thrombosis, oxygen inhalation and ventilation support are usually used to increase oxygen supply. When the patient's symptoms are life-threatening, active thrombolysis or interventional surgery should be performed to open the blood vessels as soon as possible. After the critical symptoms of cerebral thrombosis are alleviated and controlled, the patient should still adhere to good living habits and take long-term medication under the guidance of doctors. It is recommended to eat a low-salt and low-fat diet during the recovery period, eat more vegetables and fruits, avoid eating high-sodium foods such as bacon, pickles, canned food, etc., and avoid smoking and alcohol. Exercise moderately when your physical condition allows.

2. Coronary heart disease

The shortening of APTT indicates that the patient may suffer from coronary heart disease, which is often caused by coronary blood hypercoagulation leading to stenosis or blockage of the vessel lumen, resulting in corresponding myocardial ischemia, hypoxia, and necrosis. If the degree of coronary artery blockage is relatively high, the patient may have no obvious clinical symptoms in a resting state, or may only experience discomfort such as chest tightness and chest pain after activities. If the degree of coronary artery blockage is severe, the risk of myocardial infarction increases. Patients may experience chest pain, chest tightness, and shortness of breath when they are resting or emotionally excited. The pain may radiate to other parts of the body and persist without relief. For patients with acute onset of coronary heart disease, after sublingual administration of nitroglycerin or isosorbide dinitrate, see a doctor immediately, and the doctor evaluates whether coronary stent implantation or thrombolysis is needed immediately. After the acute phase, long-term antiplatelet and anticoagulant therapy is required. After discharge from the hospital, the patient should have a low-salt and low-fat diet, quit smoking and drinking, exercise properly, and pay attention to rest.