There are various types of hemorrhagic diseases, which are mainly classified clinically based on their etiology and pathogenesis. It can be divided into vascular, platelet, coagulation factor abnormalities, etc.
1.Vascular:
(1) Hereditary: hereditary telangiectasia, vascular hemophilia, and abnormal supporting tissue around blood vessels;
(2) Acquired: vascular wall damage caused by allergic purpura, simple purpura, drug-induced purpura, age-related purpura, autoimmune purpura, infection, metabolic factors, chemical factors, mechanical factors, etc.
2. Platelet properties:
(1) Thrombocytopenia: immune thrombocytopenia, drug-induced thrombocytopenia, aplastic anemia, tumor infiltration, leukemia, immune diseases, DIC, splenic hyperfunction, thrombotic thrombocytopenic purpura, etc;
(2) Thrombocytosis: Primary thrombocytosis, true polycythemia, splenectomy, swelling, inflammatory platelet dysfunction, thrombocytopenia, giant platelet syndrome, liver disease, and platelet dysfunction caused by uremia.
3. Abnormal coagulation factors:
(1 )Hereditary coagulation factor abnormalities: hemophilia A, hemophilia B, FXI, FV, FXI, FVII, FVIII, deficiency, congenital low (absent) fibrinogen, prothrombin deficiency, and complex coagulation factor deficiency;
(2) Acquired coagulation factor abnormalities: liver disease, vitamin K deficiency, acute leukemia, lymphoma, connective tissue disease, etc.
4.Hyperfibrinolysis:
(1) Primary: Hereditary deficiency of fibrinolytic inhibitors or increased plasminogen activity can easily induce hyperfibrinolysis in severe liver diseases, tumors, surgeries, and trauma;
(2) Acquired: visible in thrombosis, DIC, and severe liver disease (secondary)
Pathological increase in circulating substances, acquired inhibitors such as F VIII, FX, F XI, and F XII, autoimmune diseases, malignant tumors, increased levels of heparin like anticoagulants, and lupus anticoagulants.
Reference: [1] Xia Wei, Chen Tingmei. Clinical Hematology Testing Techniques. 6th Edition [M]. Beijing. People's Health Publishing House. 2015
Beijing SUCCEEDER https://www.succeeder.com/ as one of the leading brands in China Diagnostic market of Thrombosis and Hemostasis, SUCCEEDER has experienced teams of R&D,Production, Marketing Sales and Service Supplying coagulation analyzers and reagents, blood rheology analyzers, ESR and HCT analyzers, platelet aggregation analyzers with ISO13485, CE Certification and FDA listed.