I te nuinga o te wa ka whakamahia te D-dimer hei tohu tohu nui mo te PTE me te DVT i roto i nga mahi haumanu.I pehea i puta mai ai?

Ko te Plasma D-dimer he hua whakahekenga motuhake i hangaia e te plasmin hydrolysis i muri i te hono-whakawhitinga o te monomer fibrin ma te whakahohe i te tauwehe XIII.He tohu motuhake mo te tukanga fibrinolysis.Ko nga D-dimers i ahu mai i nga kopae fibrin hono-whakawhitinga kua whakakikoruatia e te plasmin.I te mea he kaha te thrombosis me te mahi fibrinolytic i roto i nga oko toto o te tinana, ka piki ake te D-dimer.Ko te mate o te ngakau, te mate roro, te pulmonary embolism, te thrombosis venous, te pokanga, te puku, te whakahiato i roto i te toto, te mate me te necrosis kiko ka arahi ki te D-dimer teitei.Ina koa mo nga kaumatua me nga turoro i roto i te hohipera, na te huakita me etahi atu mate, he ngawari ki te whakaheke toto toto me te arahi ki te piki D-dimer.

Ko te D-dimer te nuinga e whakaatu ana i te mahi fibrinolytic.He nui ake, he pai ranei ka kitea i roto i te hyperfibrinolysis tuarua, penei i te ahua o te hypercoagulable, te tohatoha intravascular coagulation, te mate renal, te whakakorenga o te okana, te thrombolytic therapy, me etahi atu. te pünaha fibrinolytic (përä i te DIC, ngä momo thrombus) me ngä mate e pa ana ki te pünaha fibrinolytic (pënei i te pukupuku, te mate hapu), me te aroturuki i te maimoatanga thrombolytic.

Ko nga taumata teitei o te D-dimer, he hua whakaheke fibrin, e tohu ana i te whakahekenga o te fibrin i roto i te vivo.No reira, ko te D-dimer fibrous he tohu matua mo te thrombosis vein hohonu (DVT), pulmonary embolism (PE), disseminated intravascular coagulation (DIC).

He maha nga mate e whakaohooho ana i te punaha coagulation me/ranei te punaha fibrinolytic i roto i te tinana, ka puta te pikinga o te taumata D-dimer, a ko tenei whakahoahoa e hono tata ana ki te waahi, te kaha me te maimoatanga o te mate, na i enei mate. Ko te kimi i te taumata o te D-dimer ka taea te whakamahi hei tohu arotakenga mo te tuunga o te mate, te tohu tohu me te arahi maimoatanga.

Te tono D-dimer i roto i te thrombosis uaua hohonu

Mai i a Wilson et al.I te tau 1971, ko te kitenga o te D-dimer he mea nui ki te tirotiro i te mate embolism pulmonary.Me etahi tikanga rapunga tino tairongo, ko te uara o te tinana D-dimer kino he huanga matapae kino pai mo te pulmonary embolism, a ko tona uara he 0.99.Ka taea e te hua kino te whakakore i te embolism pulmonary, na reira ka whakaiti i nga whakamatautau whakaeke, penei i te whakamaaramatanga hau me te angiography pulmonary;karohia te whakamaarama anticoagulation matapo.D - Ko te kukū o te dimer e pa ana ki te waahi o te thrombus, me te nui ake o nga kohinga i roto i nga manga nui o te pulmonary pulmonary me te iti iho o nga kohinga i roto i nga manga iti.

Ko nga D-dimers plasma kino ka whakakore i te tupono o te DVT.I whakapumautia e te Angiography he 100% te pai o te DVT mo te D-dimer.Ka taea te whakamahi mo te whakamaarama thrombolytic me te heparin anticoagulation arataki rongoa me te tirotiro whaihua.

Ka taea e D-dimer te huri i te rahi o te thrombus.Mena ka piki ano te ihirangi, ka tohu te hokinga mai o te thrombus;i te wa o te maimoatanga, kei te haere tonu te teitei, a, kaore e rereke te rahi o te thrombus, e tohu ana kaore i te whai hua te maimoatanga.