Ko te tinana o te tinana he punaha whakakotahi me te punaha anticoagulation.Ko te punaha coagulation me te punaha anticoagulation kei te pupuri i te toenga hihiri hei whakarite i te hemostasis o te tinana me te rere toto maeneene.I te wa e raru ana te toenga o te mahi a te coagulation me te anticoagulation, ka puta te toto me te thrombosis.

1. Te mahi a te tinana

Ko te nuinga o te punaha coagulation ko nga mea whakakoi.Ko nga matū e uru tika ana ki te whakakoi ka kiia ko nga mea whakakoi.E 13 nga mea e mohiotia ana mo te coagulation.

He ara whakahoahohe mutunga me nga ara whakahoahohe o waho mo te whakakorikori i nga ahuatanga o te coagulation.

I tenei wa e whakaponohia ana ko te whakakorikori o te punaha coagulation exogenous i timatahia e te kiko kiko ka whai waahi nui ki te tiimata o te coagulation.Ko te hononga tata i waenga i nga punaha o roto me waho ka whai waahi nui ki te timata me te pupuri i te tukanga whakahiato.

2. Te mahi anticoagulant a te tinana

Kei roto i te punaha anticoagulation te punaha anticoagulation pūtau me te punaha anticoagulation wai tinana.

①Pūnaha anticoagulation pūtau

E pa ana ki te phagocytosis o te tauwehe coagulation, te tauwehe kiko, te matatini prothrombin me te monomer fibrin wairewa e te punaha mononuclear-phagocyte.

②Pūnaha anticoagulation wai tinana

Tae atu ki: nga kai aukati serine protease, te pūmua C-based protease inhibitors me te tissue factor pathway inhibitors (TFPI).

3. Pūnaha Fibrinolytic me ona mahi

Ko te nuinga ko te plasminogen, te plasmin, te plasminogen activator me te aukati fibrinolysis.

Ko te mahi a te punaha fibrinolytic: te whakakore i nga pupuhi fibrin me te whakarite kia pai te rere o te toto;whai wāhi atu ki te whakatikatika i te kiko me te whakahou i nga vascular.

4. Ko te mahi o nga pūtau endothelial vascular i roto i te tukanga o te coagulation, anticoagulation me te fibrinolysis

① Te whakaputa i nga momo matū koiora;

②Whakaritea te whakaheke toto me te mahi anticoagulation;

③Whakaritea te mahi o te punaha fibrinolysis;

④ Whakaritea te taumahatanga o te toto;

⑤Wāuru ki te takawaenga o te mumura;

⑥Kia mau tonu te mahi o te microcirculation, etc.

Nga mate o te coagulation me te anticoagulant

1. He rerekee i roto i nga ahuatanga o te coagulation.

2. He rereke o nga mea anticoagulant i roto i te plasma.

3. He rereke o te tauwehe fibrinolytic i roto i te plasma.

4. Nga mate o nga pūtau toto.

5. Nga oko toto rereke.