Ọkpụkpụ akwara dị omimi bụ otu n'ime ọrịa ndị a na-ahụkarị.N'ikwu okwu n'ozuzu, ihe ngosi ụlọ ọgwụ ndị a na-ahụkarị bụ ndị a: 1. Akpụkpọ anụ nke akụkụ ahụ emetụtara na-esonyere ya na itching, nke bụ isi n'ihi nkwụsị nke nlọghachi azụ nke venous nke ala ụkwụ, nkwụsị nke mpaghara na enweghị nri zuru oke, nke na-akpata ischemia akpụkpọ anụ. na hypoxia nke ala ụkwụ na itching na pigmentation.2. Ngosipụta nke ụbụrụ ụbụrụ na-egbuke egbuke dị ka njedebe mberede nke mmegharị ụkwụ, aphasia, coma, wdg. Nke a bụ n'ihi nkwụsị nke thrombosis miri emi nke dị n'akụkụ ala na nkwụsị nke veins intracranial, na-akpata mgbaàmà ndị dị n'elu.3. dyspnea mberede, ọdịda iku ume, venous thrombus na-adapụ ma na-egbochi nnukwu arịa ọbara na ngụgụ, na-ebute nnukwu embolism pulmonary.