N'okpuru ọnọdụ physiological, usoro abụọ nke coagulation ọbara na anticoagulation n'ime ahụ na-edozi nguzozi siri ike iji mee ka ọbara na-eru n'ime arịa ọbara.Ọ bụrụ na nguzozi ahụ adịghị n'usoro, usoro mgbochi mgbochi na-akawanye njọ na ọbara ọgbụgba na-adịkarị mfe ime, na usoro coagulation bụ nke kachasị na thrombosis na-adịkarị mfe ime.Sistemụ fibrinolysis na-arụ ọrụ dị mkpa na thrombolysis.Taa, anyị ga-ekwu maka ihe abụọ ndị ọzọ na-egosi usoro fibrinolysis, D-dimer na FDP, iji ghọta nke ọma hemostasis nke thrombin na-emepụta na thrombus nke fibrinolysis malitere.Evolution.Nye ozi gbasara ụlọ ọgwụ gbasara thrombosis na ọrụ coagulation nke ndị ọrịa.
D-dimer bụ ngwaahịa na-emebi emebi nke fibrin monomer cross-linked sitere na ihe arụrụ arụ ọrụ XIII wee mebie ya site na plasmin.D-dimer na-enweta site na eriri fibrin jikọtara ya na plasmin gbazere.D-dimer dị elu na-egosi ọnụnọ hyperfibrinolysis nke abụọ (dị ka DIC).FDP bụ okwu n'ozuzu maka ngwaahịa mmebi nke emepụtara mgbe fibrin ma ọ bụ fibrinogen gbajiri n'okpuru ọrụ plasmin emepụtara n'oge hyperfibrinolysis.FDP gụnyere fibrinogen (Fg) na fibrin monomer (FM) ngwaahịa (FgDPs), yana cross-linked fibrin degenradation ngwaahịa (FbDPs), n'ime nke FbDPs gụnyere D-dimers na ndị ọzọ iberibe, na ọkwa ha na-abawanye High na-egosi na ahụ si. Fibrinolytic ọrụ bụ hyperactive (primary fibrinolysis ma ọ bụ nke abụọ fibrinolysis)
【Ihe atụ】
A nabatara otu nwoke katarala ahụ n'ụlọọgwụ yana nsonaazụ nyocha ọbara mkpụkọ bụ nke a:
| Ihe | Nsonaazụ | Oke ntụaka |
| PT | 13.2 | 10-14 nkeji |
| APTT | 28.7 | 22-32s |
| TT | 15.4 | 14-21 nkeji |
| FIB | 3.2 | 1.8-3.5g / l |
| DD | 40.82 | 0-0.55mg/I FEU |
| FDP | 3.8 | 0-5mg / l |
| AT-III | 112 | 75-125% |
Ihe anọ nke coagulation bụ ihe na-adịghị mma, D-dimer dị mma, na FDP adịghị mma, na nsonaazụ ya na-emegiderịta onwe ya.Na mbụ chere na ọ bụ mmetụta nko, a na-enyochagharị ihe nlele ahụ site na nyocha nke mbụ na 1:10 dilution, nsonaazụ ya bụ nke a:
| Ihe | Nke mbụ | 1:10 ntụ ntụ | Oke ntụaka |
| DD | 38.45 | 11.12 | 0-0.55mg/I FEU |
| FDP | 3.4 | N'okpuru oke ala | 0-5mg / l |
Enwere ike ịhụ site na dilution na nsonaazụ FDP kwesịrị ịbụ ihe nkịtị, na D-dimer abụghị linear mgbe dilution gasịrị, a na-enyo enyo nnyonye anya.Wepụ hemolysis, lipemia, na jaundice na ọkwa nke nlele ahụ.N'ihi nsonaazụ na-ezighi ezi nke dilution, ikpe ndị dị otú ahụ nwere ike ime na nnyonye anya nkịtị na ọgwụ mgbochi heterophilic ma ọ bụ ihe rheumatoid.Lelee akụkọ ahụike nke onye ọrịa wee chọta akụkọ ihe mere eme nke ogbu na nkwonkwo rheumatoid.Laboratory Nsonaazụ nke nyocha ihe RF dị oke elu.Mgbe ya na ụlọ ọgwụ na-ekwurịta okwu, onye ọrịa ahụ kwuru ma nye akụkọ.N'ikpeazụ, onye ọrịa ahụ enweghị ihe mgbaàmà metụtara thrombus ma kpee ya ikpe na ọ bụ ụgha dị mma nke D-dimer.
【Nchịkọta】
D-dimer bụ ihe dị mkpa na-egosi mwepu na-adịghị mma nke thrombosis.Ọ nwere mmetụta dị elu, mana nkọwa kwekọrọ na ya ga-adị ike.E nwekwara akụkụ ụfọdụ nke nhụsianya ụgha.Nchikota D-dimer na FDP nwere ike ibelata akụkụ nke D-N'ihi ụgha ụgha nke dimer, mgbe ụlọ nyocha na-egosi na D-dimer ≥ FDP, ndị na-esonụ ikpe nwere ike ime na ule pụta:
1. Ọ bụrụ na ụkpụrụ dị ala (
2. Ọ bụrụ na ihe si na ya pụta bụ ọnụ ahịa dị elu (>Cut-off value), nyochaa ihe ndị na-emetụta, enwere ike inwe ihe ntinye aka.A na-atụ aro ka ịme ọtụtụ ule dilution.Ọ bụrụ na nsonaazụ ya bụ ahịrị, ezi ihe dị mma ga-akawanye njọ.Ọ bụrụ na ọ bụghị linear, ụgha positives.Ịnwekwara ike iji reagenti nke abụọ maka nkwenye ma soro ụlọọgwụ kparịta ụka n'oge.
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