A na-ejikarị D-dimer eme ihe dị ka otu n'ime ihe dị mkpa a na-enyo enyo na-egosi PTE na DVT na omume ụlọ ọgwụ.Olee otú o si mee?

Plasma D-dimer bụ ngwaahịa na-emebi emebi nke plasmin hydrolysis mepụtara mgbe ejikọtara fibrin monomer site na ịgbalite ihe XIII.Ọ bụ ihe nrịbama nke usoro fibrinolysis.A na-enweta D-dimers site na mkpirisi fibrin jikọtara ya na plasmin.Ọ bụrụhaala na enwere thrombosis na-arụ ọrụ na fibrinolytic n'ime arịa ọbara nke ahụ, D-dimer ga-abawanye.Myocardial infarction, ụbụrụ ụbụrụ, pulmonary embolism, venous thrombosis, ịwa ahụ, etuto, gbasaa coagulation intravascular, ọrịa na anụ ahụ necrosis nwere ike iduga D-dimer dị elu.Karịsịa maka ndị agadi na ndị ọrịa ụlọ ọgwụ, n'ihi nje bacteria na ọrịa ndị ọzọ, ọ dị mfe ime ka ọbara ọgbụgba na-adịghị mma ma na-eduga n'ịbawanye D-dimer.

D-dimer na-egosipụtakarị ọrụ fibrinolytic.Mmụba ma ọ bụ nke ọma hụrụ na hyperfibrinolysis nke abụọ, dị ka ọnọdụ hypercoagulable, gbasaa coagulation intravascular, ọrịa gbasara akụrụ, nkwụsị nke akụkụ ahụ, ọgwụgwọ thrombolytic, wdg. Mkpebi isi ihe nke usoro fibrinolytic bụ ihe dị ukwuu maka nchọpụta na ọgwụgwọ ọrịa nke ọrịa. usoro fibrinolytic (dị ka DIC, thrombus dị iche iche) na ọrịa ndị metụtara usoro fibrinolytic (dịka etuto ahụ, ọrịa ime ime), na nlekota nke ọgwụgwọ thrombolytic.

Ọkwa dị elu nke D-dimer, ngwaahịa mmebi fibrin, na-egosi mmebi fibrin ugboro ugboro na vivo.Ya mere, fibrous D-dimer bụ isi ihe na-egosi thrombosis miri emi (DVT), pulmonary embolism (PE), gbasaa coagulation intravascular (DIC).

Ọtụtụ ọrịa na-eme ka ọrụ nke usoro coagulation na / ma ọ bụ fibrinolytic dị n'ime ahụ, na-eme ka ọkwa D-dimer dịkwuo elu, na ntinye a na-ejikọta ya na ogbo, ogo na ọgwụgwọ ọrịa ahụ, ya mere na ọrịa ndị a. Enwere ike iji nchọpụta nke ọkwa D-dimer dị ka ihe nleba anya maka nhazi ọrịa, prognosis na nduzi ọgwụgwọ.

Ngwa nke D-dimer na thrombosis miri emi

Ebe ọ bụ na Wilson et al.Nke mbụ etinyere ngwaahịa mmebi fibrin maka nyocha nke embolism nke akpa ume na 1971, nchọpụta D-dimer arụwo nnukwu ọrụ n'ime nchọpụta nke pulmonary embolism.N'iji ụzọ nchọpụta ụfọdụ nwere mmetụta siri ike, uru ahụ D-dimer na-adịghị mma nwere mmetụta amụma na-adịghị mma maka embolism pulmonary, yana uru ya bụ 0.99.Nsonaazụ na-adịghị mma nwere ike n'ụzọ bụ isi wepụ ihe mgbakasị akpa ume, si otú ahụ belata nyocha nke mkpasu iwe, dị ka nyocha nke ikuku ventilashị na angiography pulmonary;zere ọgwụgwọ ọgwụ mgbochi kpuru ìsì.D - Ntụle nke dimer metụtara ọnọdụ nke thrombus, na-enwe mmetụta dị elu na alaka ndị bụ isi nke akpa ume na obere mkpokọta na obere alaka.

Plasma D-dimers na-adịghị mma na-ewepụ ohere nke DVT.Angiography kwadoro DVT bụ 100% dị mma maka D-dimer.Enwere ike iji ya maka ọgwụgwọ thrombolytic na ntụzịaka heparin anticoagulation ọgwụ na nleba anya arụmọrụ.

D-dimer nwere ike igosipụta mgbanwe na nha thrombus.Ọ bụrụ na ọdịnaya na-abawanye ọzọ, ọ na-egosi nlọghachi nke thrombus;n'oge usoro ọgwụgwọ, ọ na-aga n'ihu na-adị elu, na nha nke thrombus adịghị agbanwe agbanwe, na-egosi na ọgwụgwọ adịghị arụ ọrụ.