Ịrụ ọrụ coagulation bụ akụkụ nke ọrịa imeju na ihe bụ isi na-eme ka ọtụtụ akara nyocha.Mgbanwe na nguzozi nke hemostasis na-eduga n'ọbara ọgbụgba, na nsogbu ọbara ọgbụgba na-abụkarị nnukwu nsogbu ụlọ ọgwụ.Enwere ike kewaa ihe kpatara ọbara ọgbụgba n'ime (1) ọbara mgbali elu, nke na-enweghị ihe jikọrọ ya na usoro hemostatic;(2) mucosal ma ọ bụ puncture ọnya ọbara ọgbụgba, na-enwekarị mgbasa nke thrombus ma ọ bụ nnukwu fibrinolysis, nke a na-akpọ accelerated intravascular coagulation na fibrinolysis na ọrịa imeju Melt (AICF).Usoro hyperfibrinolysis abụghị nke doro anya, mana ọ gụnyere mgbanwe na coagulation intravascular na fibrinolysis.A na-ahụ coagulation na-adịghị mma na thrombosis portal vein thrombosis (PVT) na mesenteric vein thrombosis, yana thrombosis miri emi (DVT).Ọnọdụ ụlọ ọgwụ ndị a na-achọkarị ọgwụgwọ mgbochi ma ọ bụ mgbochi.Microthrombosis na imeju nke hypercoagulability kpatara na-ebutekarị atrophy imeju.
A kọwapụtala mgbanwe ụfọdụ dị mkpa na ụzọ hemostasis, ụfọdụ na-agbapụta ọbara na ndị ọzọ na-agbajikwa (Nyocha 1).N'ime imeju imeju kwụsiri ike, usoro ahụ ga-emezigharị n'ihi ihe ndị na-emebi emebi, mana nguzozi a anaghị akwụsi ike, ihe ndị ọzọ ga-emetụtakwa nke ukwuu, dị ka ọkwa olu ọbara, ọrịa sistemu, na ọrụ akụrụ.Thrombocytopenia nwere ike ịbụ mgbanwe mgbanwe ọrịa na-emekarị n'ihi hypersplenism na mbelata thrombopoietin (TPO).A kọwawokwa arụrụ ọrụ Platelet, mana mgbanwe ndị a na-egbochi ọbara ọgbụgba na-ebelata nke ukwuu site na mmụba nke von Willebrand Factor (vWF) sitere na endothelial.N'otu aka ahụ, mbelata ihe procoagulant sitere na imeju, dị ka ihe V, VII, na X, na-eduga na ogologo oge prothrombin, mana nke a na-ebelata nke ukwuu site na mbelata ihe na-egbochi imeju na-enweta (karịsịa protein C).Na mgbakwunye, ihe VIII na-enweta endothelial dị elu na protein C dị ala na-eduga na ọnọdụ hypercoagulable dịtụ.Mgbanwe ndị a, yana mgbakwunye venous stasis na mmebi endothelial (Virchow's triad), butere ọganihu mmekọrịta nke PVT na oge ụfọdụ DVT na ndị ọrịa nwere imeju imeju.Na nkenke, ụzọ hemostatic nke imeju imeju na-agbanwekarị n'ụzọ na-adịghị akwụsi ike, na ọganihu nke ọrịa ahụ nwere ike ịdaba n'akụkụ ọ bụla.
Ntụaka: O'Leary JG, Greenberg CS, Patton HM, Caldwell SH.AGA Clinical Practice Mmelite: Coagulation inCirrhosis.Gastroenterology.2019,157(1):34-43.e1.doi:10.1053/j.gastro.2019.03.070 .
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