Ọbara mkpụkọ ọbara na-eyi ndụ egwu, n'ihi na ọgbaghara bụ n'ihi ihe dị iche iche na-akpata ọgba aghara arụ ọrụ nke ahụ mmadụ.Mgbe arụ ọrụ coagulation gasịrị, usoro mgbaàmà nke ọbara ọgbụgba ga-apụta.Ọ bụrụ na ọbara ọgbụgba intracranial siri ike apụta, enwere nnukwu ihe egwu nke ndụ.N'ihi na enwere ọtụtụ ọrịa na-akpata coagulation dysfunction, nke a na-ahụkarị bụ hemophilia A, hemophilia B, hemophilia vaskụla, ụkọ vitamin K, na-agbasa arịa ọbara na vitamin Ọrịa ndị a nwere ike ibute ọrịa coagulation dysfunctional.Ọ bụrụ na ọ bụ onye ọrịa nwere nnukwu hemophilia A, enwere ike ịhụ ọbara ọgbụgba n'onwe ya.Mgbe obere mmerụ ahụ gasịrị, ọ dị mfe ịkpata ọbara ọgbụgba.Ọ bụrụ na ndị ọrịa nwere nnukwu hemophilia A na-ata ahụhụ site na trauma, ọ dị mfe ime ka ọbara ọgbụgba craniocerebral siri ike, nke na-etinye ndụ onye ọrịa ahụ n'ihe ize ndụ.Na mgbakwunye, nnukwu arịa ọbara dị n'ime ime coagulation, n'ihi oriri na arụrụ ọrụ nke coagulation nke ihe dị iche iche na-akpata coagulation, na-enwekwa ike ibute nnukwu ọbara ọgbụgba, na-eduga na ọnwụ nke onye ọrịa n'oge.