01.Nchọpụta arịa dị omimi nke thrombosis na pulmonary embolism

Ọkpụkpụ thrombosis miri emi (D-VT) na-enwekarị embolism pulmonary embolism (PE), nke akpọrọ venous thromboembolism (VTE).Ọkwa Plasma D-dimer na-ebuli elu nke ukwuu na ndị ọrịa VTE.

Nnyocha ndị metụtara ya egosila na ntinye uche D-dimer plasma na ndị ọrịa nwere PE na D-VT karịrị 1 000 μg / L.

Otú ọ dị, n'ihi ọtụtụ ọrịa ma ọ bụ ụfọdụ ihe na-akpata ọrịa (ịwa ahụ, etuto ahụ, ọrịa obi, wdg) nwere mmetụta ụfọdụ na hemostasis, na-eme ka D-dimer dịkwuo elu.Ya mere, ọ bụ ezie na D-dimer nwere mmetụta dị elu, nkọwa ya bụ nanị 50% ruo 70%, na D-dimer naanị enweghị ike ịchọpụta VTE.Ya mere, mmụba dị ịrịba ama na D-dimer enweghị ike iji mee ihe dị ka ihe ngosi kpọmkwem nke VTE.Ihe bara uru nke nnwale D-dimer bụ na nsonaazụ ọjọọ na-egbochi nchoputa nke VTE.

 

02 Kesara coagulation intravascular

Mgbasa nke intravascular coagulation (DIC) bụ ọrịa nke nnukwu microthrombosis na obere arịa dị n'ime ahụ dum yana hyperfibrinolysis nke abụọ n'okpuru omume nke ụfọdụ ihe na-akpata ọrịa, nke nwere ike iso ya na fibrinolysis nke abụọ ma ọ bụ na-egbochi fibrinolysis.

Ọdịnaya dị elu plasma nke D-dimer nwere uru ntụaka ụlọ ọgwụ dị elu maka nchọpụta mmalite nke DIC.Otú ọ dị, ekwesịrị ịmara na mmụba nke D-dimer abụghị ule a kapịrị ọnụ maka DIC, mana ọtụtụ ọrịa na-esonyere microthrombosis nwere ike iduga mmụba nke D-dimer.Mgbe fibrinolysis bụ nke abụọ na coagulation extravascular, D-dimer ga-abawanye.

Nnyocha egosiwo na D-dimer na-amalite ibili ụbọchị tupu DIC ma dị elu karịa nke nkịtị.

 

03 Asphyxia nwa ọhụrụ

Enwere ogo dị iche iche nke hypoxia na acidosis na nwa ọhụrụ asphyxia, na hypoxia na acidosis nwere ike ịkpata mmebi nke endothelial vaskụla buru ibu, na-ebute ntọhapụ nke nnukwu ihe coagulation, si otú ahụ na-abawanye mmepụta nke fibrinogen.

Nnyocha ndị dị mkpa egosila na uru D-dimer nke ọbara eriri afọ na otu asphyxia dị elu nke ukwuu karịa nke otu njikwa nkịtị, ma e jiri ya tụnyere uru D-dimer na ọbara dị n'akụkụ, ọ dịkwa elu nke ukwuu.

 

04 lupus erythematosus sistemu (SLE)

Usoro coagulation-fibrinolysis bụ ihe na-adịghị mma na ndị ọrịa SLE, na mmebi nke usoro coagulation-fibrinolysis na-apụtawanye ìhè na ọkwa nke ọrịa ahụ, na ọchịchọ nke thrombosis na-apụta ìhè karị;Mgbe ọrịa ahụ kwụsịrị, usoro coagulation-fibrinolysis na-emekarị ka ọ bụrụ ihe nkịtị.

Ya mere, a ga-abawanye ọkwa D-dimer nke ndị ọrịa nwere lupus erythematosus systemic na ọkwa na-arụ ọrụ na nke anaghị arụ ọrụ, yana ọkwa D-dimer plasma nke ndị ọrịa nọ n'ọkwa na-arụ ọrụ dị elu nke ukwuu karịa ndị na-adịghị arụ ọrụ.

05 Imeju imeju na ọrịa kansa imeju

D-dimer bụ otu n'ime ihe nrịbama na-egosipụta oke ọrịa imeju.Ka ọrịa imeju na-akawanye njọ, na-abawanye ọdịnaya D-dimer plasma.

Nnyocha ndị dị mkpa gosiri na ụkpụrụ D-dimer nke Child-Pugh A, B, na C akara ule na ndị ọrịa nwere imeju imeju bụ (2.218 ± 0.54) μg / ml, (6.03 ± 0.76) μg / ml, na (10.536 ± ±). 0.664) μg/ml, n'otu n'otu..

Tụkwasị na nke ahụ, D-dimer na-ebuli elu nke ukwuu na ndị ọrịa nwere ọrịa cancer imeju na-enwe ọganihu ngwa ngwa na prognosis na-adịghị mma.

06 Ọrịa cancer afọ

Mgbe a gbasasịrị ndị ọrịa cancer, thromboembolism na-apụta n'ihe dị ka ọkara nke ndị ọrịa, na D-dimer na-abawanye nke ukwuu na 90% nke ndị ọrịa.

Na mgbakwunye, enwere otu klas nke ihe ndị nwere shuga dị elu n'ime mkpụrụ ndụ tumor nke usoro ha na ihe anụ ahụ yiri ya.Isonye na mmemme metabolic mmadụ nwere ike ịkwalite ọrụ nke sistemu coagulation nke anụ ahụ ma mee ka ohere nke thrombosis dịkwuo elu, yana ọkwa D-dimer na-abawanye nke ukwuu.Ọkwa D-dimer na ndị ọrịa ọrịa kansa afọ nwere ogbo III-IV dị elu karịa nke ndị ọrịa ọrịa kansa afọ nwere ọkwa I-II.

 

07 Mycoplasma oyi baa (MMP)

MPP siri ike na-esonyere ya na ọkwa D-dimer dị elu, na ọkwa D-dimer dị elu nke ukwuu na ndị ọrịa nwere MPP siri ike karịa n'ọnọdụ dị nro.

Mgbe MPP na-arịa ọrịa siri ike, hypoxia, ischemia na acidosis ga-eme na mpaghara, tinyere mbuso agha nke nje nje, nke ga-emebi sel endothelial vaskụla, kpughee collagen, mee ka usoro coagulation rụọ ọrụ, mepụta ọnọdụ hypercoagulable, ma mepụta microthrombi.A na-arụkwa ọrụ fibrinolytic dị n'ime, kinin na sistemu mmeju nke ọma, na-ebute ọkwa D-dimer na-abawanye.

 

08 Ọrịa shuga mellitus, ọrịa shuga nephropathy

Ọkwa D-dimer dị elu nke ukwuu na ndị ọrịa nwere ọrịa shuga na ọrịa nephropathy mamịrị.

Na mgbakwunye, ndepụta D-dimer na fibrinogen nke ndị ọrịa nwere nephropathy mamịrị dị elu nke ukwuu karịa ndị nwere ụdị ọrịa shuga 2.Ya mere, na omume ụlọ ọgwụ, a pụrụ iji D-dimer mee ihe dị ka nyocha nyocha maka ịchọpụta oke ọrịa shuga na ọrịa akụrụ na ndị ọrịa.

09 Purpura nfụkasị ahụ (AP)

N'ime nnukwu oge nke AP, enwere ogo dị iche iche nke hypercoagulability ọbara yana arụ ọrụ platelet na-abawanye, na-eduga na vasospasm, nchịkọta platelet na thrombosis.

D-dimer dị elu na ụmụaka nwere AP na-adịkarị mgbe izu 2 gachara ma na-adịgasị iche n'etiti usoro ọgwụgwọ, na-egosipụta oke na ogo nke mbufụt vaskụla sistemu.

Na mgbakwunye, ọ bụkwa ihe ngosi prognostic, yana ọkwa D-dimer na-adịgide adịgide, ọrịa ahụ na-adịte aka ma na-enwekarị mmebi akụrụ.

 

10 Ime ime

Nnyocha ndị metụtara ya egosila na ihe dị ka 10% nke ndị inyom dị ime nwere ọkwa D-dimer dị elu nke ukwuu, na-atụ aro ihe ize ndụ nke mkpụkọ ọbara.

Preeclampsia bụ ihe mgbagwoju anya nke afọ ime.Isi mgbanwe pathological nke preeclampsia na eclampsia bụ ịgbalite coagulation na nkwalite fibrinolysis, na-ebute mmụba microvascular thrombosis na D-dimer.

D-dimer na-ebelata ngwa ngwa mgbe a mụsịrị nwa na ụmụ nwanyị nkịtị, mana ọ na-abawanye na ụmụ nwanyị nwere preeclampsia, ma ọ laghachighị na nkịtị ruo izu 4 ruo 6.

11 Ọrịa ọrịa akwara na-ekesa Aneurysm

Ndị ọrịa nwere nnukwu ọrịa akwara obi na-enwe ọkwa D-dimer nkịtị ma ọ bụ nke dị obere, ebe aneurysms aortic dissecting aneurysms na-ebuli elu nke ọma.

Nke a metụtara ọdịiche dị ịrịba ama na ibu thrombus na arịa akwara nke abụọ.Lumen nke akwara ọbara dị gịrịgịrị ma thrombus na akwara akwara dị obere.Mgbe aortic intima gbawasịrị, nnukwu ọbara akwara na-abanye n'ahụ mgbidi arịa iji mepụta aneurysm na-ekesa.A na-etolite ọnụ ọgụgụ buru ibu nke thrombi n'okpuru ọrụ nke usoro coagulation.

12 Ọrịa ụbụrụ dị oke njọ

N'ime nnukwu infarction ụbụrụ, thrombolysis na-akpaghị aka na ọrụ fibrinolytic nke abụọ na-abawanye, gosipụtara dị ka ọkwa D-dimer na-abawanye plasma.Ọkwa D-dimer abawanyela nke ukwuu n'oge mmalite nke nnukwu infarction ụbụrụ.

Plasma D-dimer ọkwa na ndị ọrịa nwere nnukwu ọrịa strok ischemic dị ntakịrị mụbara n'ime izu mbụ mgbe mmalite, mụbara nke ukwuu n'ime izu 2 ruo 4, ọ dịghịkwa iche na ọkwa nkịtị n'oge oge mgbake (> ọnwa 3).