N'ime afọ ime nkịtị, mmepụta obi na-abawanye na nguzogide akụkụ na-ebelata na afọ ime na-abawanye.A na-ekwenyekarị na mmepụta obi na-amalite ịba ụba na izu 8 ruo 10 nke ime ime, na-erukwa ọnụ ọgụgụ kasị elu na izu 32 ruo 34 nke ime ime, nke bụ 30% ruo 45% karịa nke ahụ na-abụghị ime ime, ma na-edobe ọkwa a ruo mgbe. nnyefe.Mbelata nke nguzogide vaskụla dị n'akụkụ na-ebelata ọbara mgbali elu, na ọbara mgbali elu diastolic na-ebelata nke ukwuu, na ọdịiche nrụgide pulse na-abawanye.Site na izu 6 ruo 10 nke ime ime, ọnụ ọgụgụ ọbara nke ụmụ nwanyị dị ime na-abawanye site na mmụba nke afọ ime, ma na-abawanye site na 40% na njedebe nke afọ ime, mana mmụba nke plasma ọbara karịrị ọnụ ọgụgụ ọbara ọbara uhie, plasma. na-abawanye site na 40% ruo 50%, mkpụrụ ndụ ọbara uhie na-abawanye site na 10% ruo 15%.Ya mere, n'ime afọ ime nkịtị, a na-agbanye ọbara ahụ, na-egosipụta dị ka viscosity ọbara na-ebelata, hematocrit na-ebelata, na ụbara sedimentation erythrocyte [1].

Ihe na-akpata coagulation ọbara Ⅱ, Ⅴ, VII, Ⅷ, IX, na Ⅹ niile na-abawanye n'oge ime ime, ma nwee ike iru 1.5 ruo 2.0 ugboro nke nkịtị n'ime etiti na mbubreyo ime ime, na ọrụ nke coagulation factor Ⅺ na  mbelata.Fibrinopeptide A, fibrinopeptide B, thrombinogen, platelet factor Ⅳ na fibrinogen mụbara nke ukwuu, ebe antithrombin Ⅲ na protein C na protein S belatara.N'oge ime ime, oge prothrombin na oge prothrombin akụkụ nke na-arụ ọrụ na-ebelata, ọdịnaya fibrinogen plasma na-abawanye nke ukwuu, nke nwere ike ịbawanye ruo 4-6 g / L n'ime ọnwa atọ nke atọ, nke dị ihe dị ka 50% karịa nke ndị na-adịghị ime ime. oge.Na mgbakwunye, plasminogen mụbara, euglobulin mgbasa oge na-adị ogologo, na coagulation-anticoagulation mgbanwe mere ka ahụ na hypercoagulable ọnọdụ, nke bara uru hemostasis dị irè mgbe placental abruption n'oge ọrụ.Na mgbakwunye, ihe ndị ọzọ hypercoagulable n'oge ime ime gụnyere mmụba nke mkpokọta cholesterol, phospholipids na triacylglycerol n'ime ọbara, androgen na progesterone zoro ezo site na placenta na-ebelata mmetụta nke ụfọdụ ihe mgbochi coagulation ọbara, placenta, uterine decidua na embrayo.Ọnụnọ nke ihe ndị thromboplastin, wdg, nwere ike ịkwalite ọbara ka ọ bụrụ ọnọdụ hypercoagulable, na mgbanwe a na-abawanye na mmụba nke afọ ime.Hypercoagulation na-agafeghị oke bụ ihe nchebe physiological, nke bara uru iji nọgide na-etinye fibrin n'ime akwara, mgbidi uterine na placental villi, na-enyere aka ịnọgide na-eguzosi ike n'ezi ihe nke placenta ma na-emepụta thrombus n'ihi ịkwapụ, ma mee ka hemostasis ngwa ngwa n'oge na mgbe a mụsịrị ya., bụ usoro dị mkpa iji gbochie ọbara ọgbụgba mgbe ọmụmụ nwa.N'otu oge ahụ nke coagulation, ọrụ fibrinolytic nke abụọ na-amalitekwa wepụ thrombus na uterine spiral arteries na venous sinuses ma mee ka mmụghachi na nrụzi nke endometrium [2].

Agbanyeghị, ọnọdụ hypercoagulable nwekwara ike ịkpata ọtụtụ nsogbu ịmụ nwa.N'afọ ndị na-adịbeghị anya, nchọpụta achọpụtala na ọtụtụ ndị inyom dị ime na-enwekarị thrombosis.Ọnọdụ ọrịa a nke thromboembolism na ụmụ nwanyị dị ime n'ihi mmebi mkpụrụ ndụ ihe nketa ma ọ bụ nweta ihe ize ndụ dị ka protein anticoagulant, coagulation factor, na protein fibrinolytic ka a na-akpọ thrombosis.(thrombophilia), nke a makwaara dị ka steeti prothrombotic.Ọnọdụ prothrombotic a apụtaghị na ọ ga-ebute ọrịa thrombotic, mana ọ nwere ike ibute nsonaazụ afọ ime na-adịghị mma n'ihi enweghị nha na usoro coagulation-anticoagulation ma ọ bụ ọrụ fibrinolytic, microthrombosis nke akwara uterine spiral arteries ma ọ bụ villus, na-akpata perfusion placental na-adịghị mma ma ọ bụ ọbụna infarction, dị ka Preeclampsia. , placental abruption, placental infarction, disseminated intravascular coagulation (DIC), mgbochi nwa ebu n'afọ, ime ọpụpụ ugboro ugboro, ịmụ nwa na ịmụ nwa, wdg, nwere ike ibute ọnwụ nke nne na n'afọ n'ọnọdụ siri ike.