TT yog hais txog lub sijhawm ntshav txhaws tom qab ntxiv cov txheej txheem thrombin rau cov ntshav ntshav.Nyob rau hauv txoj kev sib txuam coagulation, cov thrombin generated hloov fibrinogen rau hauv fibrin, uas tuaj yeem cuam tshuam los ntawm TT.Vim tias fibrin (proto) degradation cov khoom (FDP) tuaj yeem txuas ntxiv TT, qee tus neeg siv TT raws li kev tshuaj ntsuam xyuas rau fibrinolytic system.
Clinical tseem ceeb:
(1) TT ntev (ntau tshaj 3s ntau tshaj li kev tswj hwm ib txwm muaj) heparin thiab heparinoid tshuaj nce ntxiv, xws li lupus erythematosus, kab mob siab, kab mob raum, thiab lwm yam. Tsawg (tsis muaj) fibrinogenemia, fibrinogenemia txawv txav.
(2) FDP nce: xws li DIC, thawj fibrinolysis thiab lwm yam.
Lub sij hawm ntev thrombin (TT) pom nyob rau hauv qhov txo qis ntawm plasma fibrinogen lossis kev ua haujlwm txawv txav;daim ntawv thov kev kho mob ntawm heparin, los yog nce heparin-zoo li anticoagulants nyob rau hauv kab mob siab, kab mob raum thiab systemic lupus erythematosus;hyperfunction ntawm fibrinolytic system.Shortened thrombin lub sij hawm yog pom nyob rau hauv lub xub ntiag ntawm calcium ions nyob rau hauv cov ntshav, los yog cov ntshav yog acidic, thiab lwm yam.
Thrombin lub sij hawm (TT) yog ib qho kev xav ntawm cov tshuaj anticoagulant hauv lub cev, yog li nws qhov txuas ntxiv qhia tias hyperfibrinolysis.Kev ntsuas yog lub sij hawm tsim ntawm fibrin tom qab ntxiv cov txheej txheem thrombin, yog li nyob rau hauv qis (tsis muaj) fibrinogen kab mob, DIC thiab ntev nyob rau hauv muaj cov tshuaj heparinoid (xws li heparin therapy, SLE thiab kab mob siab, thiab lwm yam).Kev txo qis ntawm TT tsis muaj qhov tseem ceeb hauv kev kho mob.
Li qub:
Tus nqi ib txwm yog 16 ~ 18s.Tshaj qhov kev tswj ib txwm muaj rau ntau tshaj 3s yog qhov txawv txav.
Nco tseg:
(1) Plasma yuav tsum tsis pub tshaj 3h ntawm chav tsev kub.
(2) Disodium edetate thiab heparin yuav tsum tsis txhob siv los ua anticoagulants.
(3) Thaum kawg ntawm qhov kev sim, txoj kev sim tube yog raws li qhov pib coagulation thaum turbidity tshwm;txoj kev iav tais yog raws li lub peev xwm los provoke fibrin filaments
Cov kab mob ntsig txog:
Lupus erythematosus