Nyob rau hauv physiological tej yam kev mob, lub luag hauj lwm ntawm thrombosis yog kom tsis txhob los ntshav.Kev kho cov ntaub so ntswg thiab lub cev yuav tsum ua ntej kom tsis txhob los ntshav.Hemophilia yog coagulopathy tshwm sim los ntawm qhov tsis muaj coagulation tshuaj.Nws yog ib qho nyuaj rau tsim thrombus nyob rau hauv qhov chaw raug mob thiab tsis tuaj yeem nres los ntshav thiab ua rau los ntshav.Feem ntau hemostatic thrombosis cov ntaub ntawv thiab tshwm sim sab nraum cov hlab ntsha los yog cov hlab ntsha tawg.

Yog tias cov ntshav txhaws tshwm sim hauv cov hlab ntsha, cov ntshav ntws hauv cov hlab ntsha raug thaiv, cov ntshav khiav qis, lossis txawm tias cov ntshav ntws cuam tshuam.Yog tias thrombosis tshwm sim hauv cov hlab ntsha, nws yuav ua rau lub cev / cov nqaij ntshiv ischemia thiab txawm tias necrosis, xws li myocardial infarction, cerebral infarction, thiab qis extremity necrosis / amputation.Cov thrombus tsim nyob rau hauv cov hlab ntsha sib sib zog nqus ntawm cov qis extremities tsis tsuas yog cuam tshuam cov venous ntshav mus rau hauv lub plawv thiab ua o ntawm lub qis extremities, tab sis kuj ntog los ntawm inferior vena cava, txoj cai atrium thiab txoj cai ventricle nkag mus rau hauv thiab incarcerate mus rau hauv lub qis extremities. pulmonary hlab ntsha, ua rau pulmonary embolism.Cov kab mob uas muaj cov neeg tuag coob.

Thrombosis pib

Feem ntau, qhov pib txuas ntawm thrombosis yog kev raug mob, uas tuaj yeem raug mob, phais, plaque rupture hauv cov hlab ntsha, lossis txawm tias endothelial puas tsuaj los ntawm kev kis kab mob, tiv thaiv kab mob thiab lwm yam.Cov txheej txheem ntawm thrombus tsim los ntawm kev raug mob hu ua exogenous coagulation system.Hauv ob peb kis, ntshav stasis lossis qeeb ntawm cov ntshav khiav tuaj yeem pib ua cov txheej txheem ntawm thrombosis, uas yog ib txoj hauv kev sib cuag, hu ua endogenous coagulation system.

Thawj hemostasis

Thaum qhov kev raug mob cuam tshuam rau cov hlab ntsha, cov platelets ua ntej ua ib txheej los npog lub qhov txhab, thiab tom qab ntawd raug qhib kom sib sau ua ke, uas yog platelet thrombi.Tag nrho cov txheej txheem yog hu ua thawj hemostasis.

Secondary hemostasis

Qhov kev raug mob tso tawm cov tshuaj coagulation hu ua cov ntaub so ntswg, uas pib lub endogenous coagulation system los tsim thrombin tom qab nkag mus rau hauv cov ntshav.Thrombin yog tiag tiag ib tug catalyst uas hloov cov coagulation protein nyob rau hauv cov ntshav, uas yog, fibrinogen rau hauv fibrin., Tag nrho cov txheej txheem hu ua Secondary hemostasis.

"Kev sib tham zoo meej"Thrombosis

Nyob rau hauv tus txheej txheem ntawm thrombosis, thawj theem ntawm hemostasis (platelet adhesion, ua kom thiab aggregation) thiab theem ob ntawm hemostasis (thrombin ntau lawm thiab fibrin tsim) koom tes nrog ib leeg.Qhov thib ob-theem hemostasis tuaj yeem tsuas yog ua tau ib txwm muaj nyob rau hauv lub xub ntiag ntawm platelets, thiab cov tsim thrombin ntxiv activates cov platelets.Ob leeg ua hauj lwm ua ke thiab ua hauj lwm ua ke kom tiav cov txheej txheem ntawm thrombosis.