Nyob rau hauv physiological tej yam kev mob, ob lub cev ntawm cov ntshav coagulation thiab anticoagulation nyob rau hauv lub cev muaj ib tug dynamic tshuav nyiaj li cas kom cov ntshav ntws nyob rau hauv cov hlab ntsha.Yog tias qhov sib npaug tsis sib npaug, cov kab mob anticoagulation yog qhov tseem ceeb thiab cov ntshav tawm tuaj yeem tshwm sim, thiab cov kab mob coagulation yog qhov tseem ceeb thiab thrombosis yog qhov tshwm sim.Lub fibrinolysis system plays lub luag haujlwm tseem ceeb hauv thrombolysis.Niaj hnub no peb yuav tham txog lwm ob qhov ntsuas ntawm fibrinolysis system, D-dimer thiab FDP, kom nkag siab tag nrho cov hemostasis tsim los ntawm thrombin mus rau thrombus pib los ntawm fibrinolysis.Evolution.Muab cov ntaub ntawv kho mob yooj yim txog cov neeg mob thrombosis thiab coagulation muaj nuj nqi.
D-dimer yog ib yam khoom degradation uas tsim los ntawm fibrin monomer cross-linked los ntawm activated factor XIII thiab ces hydrolyzed los ntawm plasmin.D-dimer yog muab los ntawm cross-linked fibrin clot yaj los ntawm plasmin.Elevated D-dimer qhia tias muaj cov hyperfibrinolysis theem nrab (xws li DIC).FDP yog lub ntsiab lus dav dav rau cov khoom degradation uas tsim tom qab fibrin lossis fibrinogen tawg nyob rau hauv qhov kev txiav txim ntawm plasmin ua thaum lub sij hawm hyperfibrinolysis.FDP suav nrog cov khoom siv fibrinogen (Fg) thiab fibrin monomer (FM) cov khoom (FgDPs), nrog rau cov khoom sib txuas ntawm fibrin degradation (FbDPs), cov FbDPs suav nrog D-dimers thiab lwm yam tawg, thiab lawv qib nce siab qhia tias lub cev lub cev. Kev ua haujlwm fibrinolytic yog hyperactive (thawj fibrinolysis lossis theem nrab fibrinolysis)
【Piv txwv】
Ib tug txiv neej hnub nyoog nruab nrab tau mus rau hauv tsev kho mob thiab cov txiaj ntsig ntawm kev kuaj ntshav txhaws tau raws li hauv qab no:
| Yam khoom | Kev tshwm sim | Kev siv ntau yam |
| PT | 13.2 | 10-14 hnub |
| APTT | 28.7 ib | 22-32 s. : kuv |
| TT | 15.4 ib | 14-21 : kuv |
| FIB | 3.2 | 1.8-3.5g / l |
| DD | 40.82 ib | 0-0.55 mg/I FEU |
| FDP | 3.8 | 0-5 mg/l |
| AB-III | 112 | 75-125% |
Plaub yam khoom ntawm coagulation yog tag nrho qhov tsis zoo, D-dimer yog qhov zoo, thiab FDP yog qhov tsis zoo, thiab cov txiaj ntsig tau tsis sib haum.Thaum xub thawj xav tias yog ib qho kev sib txuas, cov qauv tau rov kuaj xyuas los ntawm qhov qub ntau yam thiab 1:10 dilution test, qhov tshwm sim yog raws li nram no:
| Yam khoom | Keeb kwm | 1:10 dilution | Kev siv ntau yam |
| DD | 38.45 Nws | 11.12 Nws | 0-0.55 mg/I FEU |
| FDP | 3.4 | Hauv qab qhov kev txwv qis | 0-5 mg/l |
Nws tuaj yeem pom los ntawm kev hloov pauv uas FDP qhov tshwm sim yuav tsum yog qhov qub, thiab D-dimer tsis yog linear tom qab dilution, thiab kev cuam tshuam yog xav tau.Tsis suav nrog hemolysis, lipemia, thiab jaundice los ntawm cov xwm txheej ntawm cov qauv.Vim tias qhov tsis txaus ntseeg ntawm qhov dilution, cov xwm txheej zoo li no yuav tshwm sim hauv kev cuam tshuam nrog heterophilic antibodies lossis rheumatoid yam.Tshawb xyuas tus neeg mob cov keeb kwm kho mob thiab nrhiav keeb kwm ntawm rheumatoid mob caj dab.Laboratory Cov txiaj ntsig ntawm RF qhov kev kuaj xyuas tau zoo heev.Tom qab sib txuas lus nrog lub tsev kho mob, tus neeg mob tau hais thiab tshaj tawm tsab ntawv ceeb toom.Hauv kev soj ntsuam tom qab, tus neeg mob tsis muaj cov tsos mob ntsig txog thrombus thiab raug txiav txim tias yog qhov tsis zoo ntawm D-dimer.
【Summarize】
D-dimer yog ib qho tseem ceeb qhia txog kev tsis pom zoo ntawm cov thrombosis.Nws muaj qhov rhiab heev, tab sis qhov sib thooj tshwj xeeb yuav tsis muaj zog.Kuj tseem muaj qee qhov kev faib ua feem ntawm qhov tsis zoo.Kev sib xyaw ua ke ntawm D-dimer thiab FDP tuaj yeem txo qis ib feem ntawm D- Rau qhov tsis tseeb qhov zoo ntawm dimer, thaum kuaj pom tias D-dimer ≥ FDP, cov kev txiav txim hauv qab no tuaj yeem ua rau ntawm qhov kev xeem:
1. Yog tias cov nqi qis (
2. Yog tias qhov tshwm sim yog tus nqi siab (> Tus nqi txiav tawm), txheeb xyuas qhov cuam tshuam, tej zaum yuav muaj qhov cuam tshuam.Nws raug nquahu kom ua ntau qhov kev sim dilution.Yog tias qhov tshwm sim yog linear, qhov tseeb qhov zoo yog qhov zoo dua.Yog hais tias nws tsis yog linear, cuav zoo.Koj tseem tuaj yeem siv cov reagent thib ob rau kev kuaj xyuas thiab sib txuas lus nrog lub tsev kho mob hauv lub sijhawm.
Daim npav ua lag luam
Suav WeChat
Lus Askiv WeChat