Cov kws tshawb fawb ntawm Monash University tau tsim cov tshuaj tiv thaiv tshiab uas tuaj yeem cuam tshuam cov protein tshwj xeeb hauv cov ntshav los tiv thaiv thrombosis yam tsis muaj kev phiv.Cov tshuaj tiv thaiv no tuaj yeem tiv thaiv kab mob thrombosis, uas tuaj yeem ua rau lub plawv nres thiab mob stroke yam tsis muaj kev cuam tshuam rau cov ntshav txhaws.

Lub plawv nres thiab mob stroke tseem yog qhov ua rau muaj kev tuag thiab mob thoob ntiaj teb.Cov tshuaj antithrombotic (anticoagulant) tam sim no tuaj yeem ua rau muaj teeb meem los ntshav loj vim tias lawv tseem cuam tshuam nrog cov ntshav txhaws.Plaub feem tsib ntawm cov neeg mob tau txais kev kho mob antiplatelet tseem muaj cov xwm txheej ntawm cov hlab plawv rov tshwm sim.

Yog li ntawd, cov tshuaj antiplatelet uas twb muaj lawm tsis tuaj yeem siv rau hauv cov koob tshuaj loj.Yog li ntawd, qhov kev ua tau zoo ntawm kev kho mob tseem ua rau poob siab, thiab cov kev kho mob yav tom ntej yuav tsum tau kho dua tshiab.

Txoj kev tshawb fawb yog thawj zaug txiav txim siab txog kev sib txawv ntawm kev sib txawv ntawm ib txwm coagulation thiab pathological coagulation, thiab pom tias von Willebrand factor (VWF) hloov nws cov khoom thaum muaj teeb meem thrombus tsim.Txoj kev tshawb no tsim cov tshuaj tiv thaiv kab mob uas tsuas yog kuaj pom thiab thaiv cov kab mob pathological ntawm VWF, vim tias nws tsuas ua haujlwm thaum cov ntshav txhaws dhau los ua pathological.

Txoj kev tshawb no tau tshuaj xyuas cov yam ntxwv ntawm cov tshuaj tiv thaiv anti-VWF uas twb muaj lawm thiab txiav txim siab cov yam ntxwv zoo tshaj plaws ntawm txhua cov tshuaj tiv thaiv kab mob los khi thiab thaiv VWF raws li cov kab mob coagulation.Thaum tsis muaj qhov tsis zoo tshwm sim, cov tshuaj tiv thaiv muaj peev xwm ua ntej ua ke rau hauv cov qauv ntshav tshiab los tiv thaiv cov teeb meem no.

Cov kws kho mob tam sim no tau ntsib nrog qhov sib npaug ntawm qhov ua tau zoo ntawm kev siv tshuaj thiab los ntshav.Cov tshuaj tiv thaiv engineered yog tsim tshwj xeeb thiab yuav tsis cuam tshuam nrog cov ntshav coagulation ib txwm, yog li nws vam tias nws tuaj yeem siv ntau dua thiab siv tau zoo dua li cov kev kho mob uas twb muaj lawm.

Qhov kev tshawb fawb hauv vitro no tau ua nrog kev kuaj ntshav tib neeg.Cov kauj ruam tom ntej yog los ntsuas qhov ua tau zoo ntawm cov tshuaj tiv thaiv kab mob hauv cov qauv tsiaj me kom nkag siab tias nws ua haujlwm li cas hauv kev ua neej nyob zoo ib yam li peb tus kheej.

Reference: Thomas Hoefer et al.Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 txo occlusive thrombus tsim hauv vitro, Haematologica (2020).