Nyob rau hauv ib txwm cev xeeb tub, lub plawv tso zis nce thiab peripheral tsis kam txo nrog nce lub hnub nyoog gestational.Nws feem ntau ntseeg tau tias cov txiaj ntsig ntawm lub plawv pib nce ntawm 8 mus rau 10 lub lis piam ntawm cev xeeb tub, thiab nce mus txog qhov siab kawg ntawm 32 mus rau 34 lub lis piam ntawm cev xeeb tub, uas yog 30% mus rau 45% siab tshaj qhov uas tsis yog cev xeeb tub, thiab tswj qib no kom txog rau thaum cev xeeb tub. kev xa khoom.Qhov txo qis ntawm peripheral vascular tsis kam txo qis ntshav siab, thiab diastolic ntshav siab txo qis, thiab cov mem tes siab sib txawv dav.Los ntawm 6 mus rau 10 lub lis piam ntawm cev xeeb tub, cov ntshav ntim ntawm cov poj niam cev xeeb tub nce nrog qhov nce ntawm lub hnub nyoog gestational, thiab nce li ntawm 40% thaum kawg ntawm cev xeeb tub, tab sis qhov nce ntawm cov ntshav plasma ntau dua li cov qe ntshav liab, ntshav. nce 40% mus rau 50%, thiab cov qe ntshav liab nce 10% mus rau 15%.Yog li ntawd, nyob rau hauv ib txwm cev xeeb tub, cov ntshav yog diluted, manifested raws li txo cov ntshav viscosity, txo hematocrit, thiab nce erythrocyte sedimentation tus nqi [1].

Cov ntshav coagulation yam tseem ceeb Ⅱ, Ⅴ, VII, Ⅷ, IX, thiab Ⅹ txhua qhov nce thaum cev xeeb tub, thiab tuaj yeem ncav cuag 1.5 txog 2.0 npaug ntawm qhov ib txwm muaj nyob rau nruab nrab thiab lig cev xeeb tub, thiab cov dej num ntawm coagulation yam Ⅺ thiab  txo.Fibrinopeptide A, fibrinopeptide B, thrombinogen, platelet factor Ⅳ thiab fibrinogen nce ntxiv, thaum antithrombin Ⅲ thiab protein C thiab protein S txo.Thaum cev xeeb tub, lub sijhawm prothrombin thiab lub sijhawm ua haujlwm ib feem ntawm prothrombin tau luv, thiab cov ntsiab lus ntawm cov ntshav plasma fibrinogen nce ntxiv, uas tuaj yeem nce mus rau 4-6 g / L hauv peb lub hlis thib peb, uas yog kwv yees li 50% siab dua li cov uas tsis cev xeeb tub. lub sij hawm.Tsis tas li ntawd, plasminogen nce, euglobulin dissolution lub sij hawm ntev, thiab kev hloov pauv ntawm coagulation-anticoagulation ua rau lub cev nyob rau hauv lub xeev hypercoagulable, uas muaj txiaj ntsig zoo rau hemostasis tom qab placental abruption thaum lub sij hawm ua hauj lwm.Tsis tas li ntawd, lwm yam hypercoagulable thaum cev xeeb tub suav nrog kev nce ntawm tag nrho cov roj cholesterol, phospholipids thiab triacylglycerols hauv cov ntshav, androgen thiab progesterone secreted los ntawm cov placenta txo cov nyhuv ntawm qee cov ntshav coagulation inhibitors, placenta, uterine decidua thiab embryos.Lub xub ntiag ntawm cov tshuaj thromboplastin, thiab lwm yam, tuaj yeem txhawb nqa cov ntshav kom nyob rau hauv lub xeev hypercoagulable, thiab qhov kev hloov pauv no yog exacerbated nrog kev nce ntawm lub hnub nyoog gestational.Mob hypercoagulation yog ib qho kev tiv thaiv ntawm lub cev, uas muaj txiaj ntsig zoo los tswj cov fibrin deposition hauv cov hlab ntsha, phab ntsa uterine thiab placental villi, pab tswj kev ncaj ncees ntawm cov placenta thiab daim ntawv thrombus vim stripping, thiab pab txhawb hemostasis sai thaum lub sij hawm thiab tom qab yug me nyuam., yog ib qho tseem ceeb mechanism los tiv thaiv postpartum hemorrhage.Nyob rau tib lub sijhawm ntawm coagulation, kev ua haujlwm fibrinolytic theem nrab kuj tseem pib tshem tawm cov thrombus hauv cov hlab ntsha ntawm lub tsev menyuam thiab cov hlab ntsha venous thiab ua kom lub cev rov tsim dua tshiab thiab kho cov endometrium [2].

Txawm li cas los xij, lub xeev hypercoagulable kuj tuaj yeem ua rau muaj ntau yam teeb meem ntawm obstetric.Nyob rau hauv xyoo tas los no, cov kev tshawb fawb tau pom tias ntau tus poj niam cev xeeb tub yog qhov ua rau thrombosis.Tus kab mob no lub xeev ntawm thromboembolism nyob rau hauv cov poj niam cev xeeb tub vim yog cov caj ces tsis xws luag los yog kis tau tej yam txaus ntshai xws li anticoagulant proteins, coagulation yam, thiab fibrinolytic proteins hu ua thrombosis.(thrombophilia), tseem hu ua lub xeev prothrombotic.Lub xeev prothrombotic no tsis tas yuav ua rau cov kab mob thrombotic, tab sis tuaj yeem ua rau muaj qhov tshwm sim tsis zoo ntawm cev xeeb tub vim qhov tsis sib xws hauv coagulation-anticoagulation mechanisms lossis fibrinolytic kev ua, microthrombosis ntawm uterine kauv hlab ntsha lossis villus, ua rau tsis zoo placental perfusion lossis txawm infarction, xws li Preeclampsia. , placental abruption, placental infarction, disseminated intravascular coagulation (DIC), fetal growth restriction, recurrent miscarriage, stillbirth and premature birth, etc., tuaj yeem ua rau niam thiab txiv tuag rau qhov mob hnyav.