(1) D-xim
Raws li cov khoom degradation ntawm cross-linked fibrin, D-dimer yog ib qho kev qhia qhia txog kev ua kom coagulation thiab theem nrab hyperfibrinolysis.Hauv cov neeg mob uas muaj COVID-19, nce qib D-dimer yog qhov cim tseem ceeb rau cov teeb meem coagulation.Cov qib D-dimer kuj tseem cuam tshuam nrog cov kab mob hnyav, thiab cov neeg mob uas muaj D-dimer nce siab ntawm kev nkag mus tau muaj qhov tshwm sim tsis zoo.Cov lus qhia los ntawm International Society of Thrombosis thiab Hemostasis (ISTH) pom zoo tias qhov nce siab D-dimer (feem ntau ntau dua 3 lossis 4 npaug ntawm qhov txwv siab tshaj plaws) tuaj yeem yog qhov qhia txog kev mus pw hauv tsev kho mob hauv COVID-19 cov neeg mob, tom qab tsis suav nrog kev txwv. Anticoagulation nrog prophylactic koob tshuaj tsawg-molecular-yuag heparin yuav tsum tau muab rau cov neeg mob sai li sai tau.Thaum D-dimer nce zuj zus thiab muaj qhov tsis txaus ntseeg siab ntawm venous thrombosis lossis microvascular embolism, anticoagulation nrog cov tshuaj kho mob heparin yuav tsum tau txiav txim siab.

Txawm hais tias qhov siab D-dimer kuj tseem tuaj yeem hais qhia hyperfibrinolysis, los ntshav propensity hauv COVID-19 cov neeg mob uas muaj qhov nce siab D-dimer yog qhov tsis tshua muaj tshwj tsis yog tias nce mus rau theem DIC hypocoagulable, qhia tias COVID-19 Cov kab mob fibrinolytic ntawm -19 tseem yog feem ntau inhibited.Lwm tus cim qhia txog fibrin, uas yog, kev hloov pauv ntawm FDP qib thiab D-dimer theem yog qhov pib zoo ib yam.

 

(2) PT
Ntev PT kuj yog ib qho kev qhia txog kev muaj peev xwm coagulation tsis zoo nyob rau hauv cov neeg mob COVID-19 thiab tau pom tias muaj feem cuam tshuam nrog kev tsis zoo.Nyob rau theem pib ntawm coagulation tsis meej nyob rau hauv COVID-19, cov neeg mob uas muaj PT feem ntau yog ib txwm ib txwm los yog me ntsis txawv txav, thiab lub PT ntev nyob rau hauv lub sij hawm hypercoagulable feem ntau qhia txog kev ua kom thiab noj ntawm exogenous coagulation yam, nrog rau kev qeeb ntawm fibrin polymerization, yog li nws kuj yog ib qho kev tiv thaiv anticoagulation.ib qho kev qhia.Txawm li cas los xij, thaum PT txuas ntxiv mus ntev heev, tshwj xeeb tshaj yog thaum tus neeg mob muaj qhov tshwm sim los ntshav, nws qhia tau hais tias cov kab mob coagulation tau nkag mus rau theem qis coagulation, los yog tus neeg mob muaj teeb meem los ntawm daim siab tsis txaus, vitamin K tsis txaus, anticoagulant overdose, thiab lwm yam. Kev hloov ntshav plasma yuav tsum tau xav txog.Lwm txoj kev kho mob.Lwm qhov kev tshuaj ntsuam xyuas coagulation, qhib ib feem ntawm thromboplastin lub sij hawm (APTT), feem ntau yog khaws cia nyob rau hauv ib txwm theem thaum lub sij hawm hypercoagulable theem ntawm coagulation disorders, uas tej zaum yuav raug ntaus nqi mus rau lub reactivity ntau VIII nyob rau hauv lub inflammatory xeev.

 

(3) Platelet suav thiab kuaj ua haujlwm
Txawm hais tias kev ua kom cov coagulation tuaj yeem ua rau txo qis platelet noj, txo cov platelet suav tsis tshua muaj tshwm sim hauv cov neeg mob COVID-19, uas tuaj yeem cuam tshuam txog kev tso tawm ntau ntxiv ntawm thrombopoietin, IL-6, cytokines uas txhawb nqa platelet reactivity hauv cov xeev inflammatory Yog li ntawd, tus nqi ntawm cov Kev suav cov platelet tsis yog qhov taw qhia rhiab heev uas cuam tshuam txog kev cuam tshuam ntawm coagulation hauv COVID-19, thiab nws yuav muaj txiaj ntsig ntau dua los saib xyuas nws cov kev hloov pauv.Tsis tas li ntawd, txo qis platelet suav yog cuam tshuam nrog kev ua haujlwm tsis zoo thiab tseem yog ib qho ntawm cov cim qhia rau prophylactic anticoagulation.Txawm li cas los xij, thaum suav txo qis (piv txwv li, <50 × 109 / L), thiab tus neeg mob muaj qhov tshwm sim los ntshav, yuav tsum tau txiav txim siab los ntawm platelet tivthaiv.

Zoo ib yam li cov txiaj ntsig ntawm kev tshawb fawb yav dhau los hauv cov neeg mob sepsis, hauv vitro platelet kev ua haujlwm kuaj hauv COVID-19 cov neeg mob uas muaj cov kab mob coagulation feem ntau tau txais txiaj ntsig tsawg, tab sis cov platelets tiag tiag hauv cov neeg mob feem ntau ua haujlwm, uas tej zaum yuav ua rau txo qis kev ua haujlwm.Cov platelets siab yog thawj zaug siv thiab siv los ntawm cov txheej txheem coagulation, thiab cov txheeb ze ntawm cov platelets hauv kev sib sau ua ke yog tsawg.

 

(4) FIB
Raws li cov theem mob hnyav heev, cov neeg mob uas muaj COVID-19 feem ntau muaj qib siab ntawm FIB nyob rau theem mob hnyav, uas tsis yog cuam tshuam rau qhov mob hnyav, tab sis qhov nce siab FIB nws tus kheej kuj yog ib qho kev pheej hmoo rau thrombosis, yog li. nws tuaj yeem siv los ua COVID-19 Ib qho ntawm cov lus qhia rau kev tiv thaiv coagulation hauv cov neeg mob.Txawm li cas los xij, thaum tus neeg mob muaj qhov nce zuj zus hauv FIB, nws yuav qhia tau tias cov kab mob coagulation tau nce mus rau theem hypocoagulable, lossis tus neeg mob muaj lub siab tsis txaus, uas feem ntau tshwm sim nyob rau theem kawg ntawm tus kab mob, thaum FIB <1.5 g. /L thiab nrog los ntshav, FIB infusion yuav tsum tau txiav txim siab.