Clinical tseem ceeb ntawm PT APTT FIB test nyob rau hauv cov neeg mob kab mob siab B


Sau: Succeeder   

Cov txheej txheem coagulation yog dej tsaws tsag-hom protein enzymatic hydrolysis txheej txheem uas muaj txog 20 yam khoom, feem ntau yog cov plasma glycoproteins synthesized los ntawm daim siab, yog li lub siab ua lub luag haujlwm tseem ceeb hauv cov txheej txheem hemostasis hauv lub cev.Los ntshav yog ib qho mob tshwm sim ntawm kab mob siab ( kab mob siab), tshwj xeeb tshaj yog cov neeg mob hnyav, thiab yog ib qho tseem ceeb ntawm kev tuag.

Lub siab yog ib qho chaw rau synthesizing ntau yam coagulation yam, thiab muaj peev xwm synthesize thiab inactivate fibrin lysates thiab antifibrinolytic tshuaj, thiab ua si lub luag hauj lwm tswj nyob rau hauv lub dynamic tshuav nyiaj li cas ntawm lub coagulation thiab anticoagulation system.Kev kuaj pom cov ntshav coagulation indexes hauv cov neeg mob uas muaj kab mob siab B tau pom tias tsis muaj qhov sib txawv tseem ceeb hauv PTAPTT hauv cov neeg mob uas muaj kab mob siab B, piv nrog cov pab pawg tswj ib txwm (P> 0.05), tab sis muaj qhov sib txawv tseem ceeb hauv FIB (P<0.05). ).Muaj qhov sib txawv tseem ceeb hauv PT, APTT, thiab FIB ntawm pawg kab mob siab B mob hnyav thiab pab pawg tswj hwm ib txwm muaj (P<005P<0.01), uas tau ua pov thawj tias qhov hnyav ntawm tus kab mob siab B tau zoo cuam tshuam nrog kev txo qis ntawm cov ntshav coagulation theem.

Kev tshuaj xyuas ntawm cov laj thawj rau cov txiaj ntsig saum toj no:

1. Tsuas yog IV (Ca*) thiab cytoplasm, lwm yam plasma coagulation yog synthesized nyob rau hauv daim siab;anticoagulation yam tseem ceeb (coagulation inhibitors) xws li ATIPC, 2-MaI-AT, thiab lwm yam kuj yog synthesized los ntawm lub siab.cellular synthesis.Thaum lub siab lub hlwb puas los yog necrotic mus rau txawv degrees, lub peev xwm ntawm lub siab los ua ke coagulation yam thiab anti-coagulation yam yog txo, thiab cov plasma theem ntawm cov yam tseem ceeb no kuj txo, uas ua rau muaj teeb meem rau lub coagulation mechanism.PT yog kev tshuaj ntsuam xyuas ntawm extrinsic coagulation system, uas tuaj yeem cuam tshuam txog qib, kev ua haujlwm thiab kev ua haujlwm ntawm coagulation factor IV VX hauv ntshav.Kev txo qis ntawm cov ntsiab lus saum toj no lossis cov kev hloov pauv hauv lawv cov dej num thiab kev ua haujlwm tau dhau los ua ib qho laj thawj rau lub sijhawm ntev PT hauv cov neeg mob uas muaj kab mob siab B cirrhosis thiab kab mob siab B. Yog li ntawd, PT feem ntau siv hauv kev kho mob los cuam tshuam cov synthesis ntawm coagulation. yam hauv siab.

2. Ntawm qhov tod tes, nrog rau kev puas tsuaj ntawm daim siab hlwb thiab lub siab tsis ua haujlwm hauv cov neeg mob kab mob siab B, qib ntawm plasmin hauv ntshav nce ntxiv rau lub sijhawm no.Plasmin tsis tuaj yeem tsuas yog hydrolyze ntau ntawm fibrin, fibrinogen thiab ntau coagulation yam xws li kev cob qhia, XXX, VVII,, thiab lwm yam, tab sis kuj tseem noj ntau ntawm cov tshuaj tiv thaiv coagulation xws li ATPC thiab lwm yam.Yog li ntawd, nrog rau kev sib sib zog nqus ntawm tus kab mob, APTT ncua ntev thiab FIB txo qis hauv cov neeg mob kab mob siab B.

Hauv kev xaus, kev kuaj pom cov coagulation indexes xws li PTAPTTFIB muaj qhov tseem ceeb heev hauv kev kho mob rau kev txiav txim rau cov neeg mob uas muaj kab mob siab B, thiab yog qhov ntsuas qhov ntsuas tau zoo thiab txhim khu kev qha.