Lub cev ib txwm muaj kev ua tiav coagulation thiab anticoagulation system.Lub coagulation system thiab anticoagulation system tswj kom muaj qhov sib npaug kom ntseeg tau tias lub cev hemostasis thiab cov ntshav ntws zoo.Thaum lub coagulation thiab anticoagulation muaj nuj nqi tshuav yog cuam tshuam, nws yuav ua rau los ntshav thiab thrombosis nyiam.

1. Lub cev coagulation muaj nuj nqi

Lub coagulation system feem ntau yog tsim los ntawm coagulation yam.Cov tshuaj cuam tshuam ncaj qha rau hauv coagulation yog hu ua coagulation factor.Muaj 13 yam uas pom tau tias coagulation.

Muaj cov txheej txheem endogenous activation thiab exogenous activation txoj hauv kev rau kev ua kom cov coagulation yam.

Nws yog tam sim no ntseeg hais tias kev ua kom lub exogenous coagulation system pib los ntawm cov ntaub so ntswg yam plays lub luag hauj lwm tseem ceeb nyob rau hauv pib ntawm coagulation.Kev sib raug zoo ntawm cov txheej txheem coagulation sab hauv thiab sab nraud plays lub luag haujlwm tseem ceeb hauv kev pib thiab tswj cov txheej txheem coagulation.

2. Lub cev ua haujlwm anticoagulant

Anticoagulation system muaj xws li cellular anticoagulation system thiab lub cev kua anticoagulation system.

①Cell anticoagulation system

Hais txog phagocytosis ntawm coagulation factor, cov ntaub so ntswg factor, prothrombin complex thiab soluble fibrin monomer los ntawm mononuclear-phagocyte system.

② Lub cev kua dej anticoagulation system

Xws li: serine protease inhibitors, protein C-raws li protease inhibitors thiab cov nqaij mos pathway inhibitors (TFPI).

3. Fibrinolytic system thiab nws cov haujlwm

Feem ntau suav nrog plasminogen, plasmin, plasminogen activator thiab fibrinolysis inhibitor.

Lub luag haujlwm ntawm fibrinolytic system: dissolve fibrin clots thiab xyuas kom meej cov ntshav ncig;koom rau hauv cov ntaub so ntswg kho thiab vascular regeneration.

4. Lub luag haujlwm ntawm vascular endothelial hlwb hauv cov txheej txheem coagulation, anticoagulation thiab fibrinolysis

① Tsim ntau yam tshuaj lom neeg lom neeg;

② Tswj cov ntshav coagulation thiab anticoagulation muaj nuj nqi;

③ Kho cov haujlwm ntawm fibrinolysis system;

④ Tswj vascular nro;

⑤ koom nrog kev kho mob ntawm qhov mob;

⑥ Tswj kev ua haujlwm ntawm microcirculation, thiab lwm yam.

Coagulation thiab anticoagulant teeb meem

1. Qhov txawv txav ntawm coagulation yam.

2. Qhov txawv txav ntawm cov tshuaj tiv thaiv coagulant hauv plasma.

3. Qhov txawv txav ntawm fibrinolytic yam nyob rau hauv plasma.

4. Cov qe ntshav txawv txav.

5. Cov hlab ntsha txawv txav.