ʻO FIB ka ʻōlelo Pelekane no ka fibrinogen, a ʻo ka fibrinogen kahi mea hoʻohui.ʻO ka waiwai FIB coagulation koko kiʻekiʻe, ʻo ia ka mea aia ke koko i kahi kūlana hypercoagulable, a ua maʻalahi ka thrombus.
Ma hope o ka hana ʻana o ke ʻano coagulation kanaka, lilo ka fibrinogen i ka monomer fibrin ma lalo o ka hana o ka thrombin, a hiki i ka monomer fibrin ke hōʻuluʻulu i ka polymer fibrin, he mea kōkua ia no ka hoʻokumu ʻana i ke koko a he mea nui i ka hana coagulation.
Hoʻopili nui ʻia ka Fibrinogen e nā hepatocytes a he protein me ka hana coagulation.Aia kona waiwai maʻamau ma waena o 2~4qL.ʻO ka Fibrinogen kahi mea e pili ana i ka coagulation, a ʻo kona hoʻonui pinepine ʻana he hopena ʻaʻole kikoʻī o ke kino a he mea pilikia ia no nā maʻi pili thromboembolism.
Hiki ke hoʻonui ʻia ka waiwai o ka coagulation FIB i nā maʻi he nui, nā genetic maʻamau a i ʻole nā mea inflammatory, nā lipid koko kiʻekiʻe, ke koko koko.
ʻO ka maʻi kiʻekiʻe, ka maʻi maʻi puʻuwai, ka maʻi diabetes, ka maʻi maʻi, ka maʻi pili, ka maʻi puʻuwai, a me nā maʻi maʻi ʻino.i ka loaʻa ʻana o nā maʻi āpau i luna aʻe e hiki ke alakaʻi i ke ʻano o ke koko koko.No laila, ʻo ka waiwai FIB coagulation koko kiʻekiʻe e pili ana i kahi kūlana o ka coagulation koko kiʻekiʻe.
ʻO ke kiʻekiʻe o ka fibrinogen, ʻo ia hoʻi, aia ke koko i ke ʻano o ka hypercoagulability a hiki i ka thrombosis.ʻIke ʻia ʻo Fibrinogen ma ke ʻano he coagulation factor I. Inā he coagulation endogenous a i ʻole coagulation exogenous, ʻo ka hana hope o ka fibrinogen e hoʻāla i nā fibroblasts.Hoʻopili liʻiliʻi ʻia nā protein i loko o kahi pūnaewele e hana i nā ʻōpū koko, no laila ke hōʻike nei ka fibrinogen i ka hana o ke koko coagulation.
Hoʻopili nui ʻia ka fibrinogen e ke ake a hiki ke hoʻokiʻekiʻe ʻia i nā maʻi he nui.ʻO nā kumu maʻamau maʻamau a i ʻole nā mea ʻeha e pili ana i nā lipids koko kiʻekiʻe, ke koko kiʻekiʻe, ka maʻi naʻau coronary, ka maʻi diabetes, ka maʻi maʻi, ka maʻi ʻiʻo pili, ka maʻi puʻuwai, a me nā Tumors malignant e piʻi aʻe.Ma hope o ka ʻoki nui ʻana, no ka mea pono ke kino e hana i ka hana hemostasis, e hoʻoulu pū ia i ka pibrinogen no ka hana hemostasis.