Kumu kumu

1. ʻEha endothelial cardiovascular
ʻO ka hōʻeha ʻana o nā pūnaʻi vascular endothelial ke kumu nui a maʻamau o ka hoʻokumu ʻana o ka thrombus, a ʻoi aku ka maʻamau i ka rumatika a me ka endocarditis infective, nā ʻeha atherosclerotic plaque koʻikoʻi, traumatic a inflammatory arteriovenous mau wahi, a me nā mea ʻē aʻe. nā endotoxins e hoʻoulu ai i nā ʻano maʻi endogenous a puni ke kino.
Ma hope o ka hōʻeha ʻana i ka ʻili, hoʻāla ka collagen ma lalo o ka endothelium i ke kaʻina coagulation, e hoʻolaha ana i ka coagulation intravascular, a me nā ʻano thrombus i ka microcirculation o ke kino holoʻokoʻa.

2. Ke kahe koko ʻole
ʻO ka mea nui e pili ana i ka emi ʻana o ke kahe o ke koko a me ka hana ʻana o nā eddies i ke kahe o ke koko, a me nā mea ʻē aʻe, a me nā mea coagulation i hoʻāla ʻia a hiki i ka thrombin i ka manaʻo i koi ʻia no ka coagulation ma ka wahi kūloko, kahi kūpono i ka hoʻokumu ʻana o ka thrombus.I waena o lākou, ʻoi aku ka maʻalahi o nā veins i ka thrombus, ka mea maʻamau i nā poʻe maʻi me ka puʻuwai puʻuwai, ka maʻi maʻi a me ka hoʻomaha moe postoperative.Eia kekahi, wikiwiki ke kahe o ke koko i loko o ka puʻuwai a me nā aʻa, a ʻaʻole maʻalahi ka hana ʻana i ka thrombus.Eia nō naʻe, ke kahe ke koko ma ka atrium hema, aneurysm, a i ʻole ka lālā o ke kīʻaha koko e lohi a hiki mai ka eddy i ka wā o ka mitral valve stenosis, hiki nō hoʻi i ka thrombosis.

3. Hoʻonui i ke koko coagulation
ʻO ka maʻamau, hoʻonui nā platelets a me nā kumu coagulation i ke koko, a i ʻole ka emi ʻana o ka hana o ka ʻōnaehana fibrinolytic, e alakaʻi ana i kahi kūlana hypercoagulable i loko o ke koko, ʻoi aku ka maʻamau i nā mokuʻāina hereditary a loaʻa.

4. Ke kūlana hypercoagulable hoʻoilina
Ua pili i ka hereditary coagulation kumu defects, congenital defects o ka protein C a me ka protein S, etc. Ma waena o lākou, ka mea maʻamau V gene mutation, ka mutation rate o keia gene hiki ke hiki i 60% i loko o nā maʻi me ka recurrent hohonu vein thrombosis.

5. Loaʻa i ke kūlana hypercoagulable
ʻIke pinepine ʻia i ka maʻi ʻaʻai pancreatic, ka maʻi ʻāmāmā, ka maʻi maʻi umauma, ka maʻi prostate, ka maʻi ʻōpū a me nā maʻi maʻi maʻi metastatic holomua ʻē aʻe, ma muli o ka hoʻokuʻu ʻia ʻana o nā mea procoagulant e nā maʻi kanesa;hiki ke hana ia ma ka ʻeha nui, ke kuni nui, ka ʻoki nui a i ʻole ka hānau ʻana I ka wā o ka nui o ke koko, a ma nā kūlana e like me ka maʻi hypertension gestational, hyperlipidemia, coronary atherosclerosis, ulaula, a me ka momona.